ArticleAnnals of medicine2026
Intelligent thermoregulation strategy versus routine thermal management on myocardial injury after noncardiac surgery during gastrointestinal tumor resection in elderly patients (SAGE): a multicenter, parallel-group, superiority trial.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInadvertent perioperative hypothermia is associated with adverse cardiovascular outcomes, but adequately powered trials using high-sensitivity troponin endpoints is lacking. The SAGE trial evaluates whether an intelligent, closed-loop thermoregulation strategy reduces myocardial injury after noncardiac surgery (MINS) in high-risk elderly patients.
methodsThis prospective, multicenter, parallel-group, randomized controlled superiority trial conducted at seven tertiary hospitals in China. Participants aged ≥65 years scheduled for elective gastrointestinal tumor resection under general anesthesia are randomly assigned (1:1) to intelligent closed-loop warming (target 36.8 °C, upper limit 37.0 °C) or routine thermal management (active warming only if core temperature ≤35.5 °C). The primary outcome is the incidence of MINS within the first 2 postoperative days , adjudicated using high-sensitivity troponin thresholds per AHA criteria. Secondary outcomes include surgical site infection, transfusion requirement, hypothermia burden, emergence delirium, delayed emergence, and postoperative shivering. With 695 participants per group (total 1,390, accounting for 10% dropout), the trial has 80% power at a one-sided significance level of 0.05 to detect a 6 absolute percentage point reduction in MINS (12% to 6%) with a superiority margin of -2 percentage points. DISCUSSION: The SAGE trial is designed to generate new evidence on the relationship between intraoperative hypothermia exposure and postoperative cardiovascular complications. It will evaluate whether closed-loop targeted normothermia reduces myocardial injury and will explore hypothermia exposure thresholds that may inform individualized perioperative management for geriatric surgical patients. TRIAL ACRONYM: Intelligent Thermoregulation
trial registrationChinese Clinical Trial Registry (ChiCTR), identifier: ChiCTR2600117264. Registered on January 21, 2026 (http://www.chictr.org.cn).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.