Observational studyInfectious diseases of poverty2026
Pragmatic weight estimation for dosing of a new paediatric treatment for schistosomiasis prevention and control in preschool-aged children: a feasibility study in Uganda and Côte d'Ivoire.
Observational study in Infectious diseases of poverty, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06698510 (Arpraziquantel for Schistosomiasis Control in Preschool-aged Children in Endemic Areas in Kenya and Côte d'Ivoire), which is not on this map. Not yet cited in PubMed.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Arpraziquantel for Schistosomiasis Control in Preschool-aged Children in Endemic Areas in Kenya and Côte d'Ivoire: A Small-scale Public Health Intervention Study Arpraziquantel for Schistosomiasis Control in Preschool-aged Children in Endemic Areas in Uganda, With Special Consideration of Dose Determination Methods: a Small-scale Public Health Intervention Study in Hoima and Bugiri Districts
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33 authors.
Funding
Abstract
backgroundSchistosomiasis remains a major public health concern in endemic settings. The Pediatric Praziquantel Consortium has developed a new paediatric treatment, arpraziquantel, for preschool-aged children. Because the treatment is dosed according to body weight, dose determination by scales poses operational challenges in community-based mass treatment campaigns. This study assessed the performance of the Pediatric Advanced Weight Prediction in the Emergency Room Extra-Long Mid-Arm Circumference (PAWPER XL-MAC) tape for weight estimation during mass drug administration in Uganda and Côte d'Ivoire.
methodsA mixed-methods study evaluated feasibility in terms of accuracy, reliability and acceptability of the PAWPER XL-MAC tape across delivery platforms and users between March 2025 and March 2026. Accuracy metrics comprised (1) the mean relative difference and mean absolute relative difference between predicted (tape) and observed (scale) weight and (2) the proportion of estimates within 10% (PW10) and 20% (PW20) of observed weight. Reliability was evaluated by calculating the intraclass-correlation coefficient (ICC). User experiences were collected through observations, questionnaires, focus group discussions and in-depth interviews.
resultsIn Uganda (n = 3369), mean absolute differences were 11.0-11.1%; PW10 60.2-61.0%. In Côte d'Ivoire (n = 1249), accuracy was higher (6.8-7.7%; PW10 72.4-78.2%). Reliability was high between users and countries (ICCs ≥ 0.84). Sufficient time for practical training was essential to achieve solid performance. With continued use, an increase in confidence, efficiency, and accuracy was observed. Qualitative results indicated strong acceptability and practical advantages amongst users.
conclusionsThis is the first study to demonstrate that the PAWPER XL-MAC tape offers reliable, accurate, and acceptable weight estimation for community-based interventions, supporting its use in routine child healthcare and public health programmes. Trial registration ClinicalTrials.gov ID NCT06698510, date of registration: 21.11.2024.
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