Trial reportRespiratory research2026
Improvement in peripheral airway function after a 12-week exercise intervention in COPD.
Trial report in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06335992 (Activation of Regenerative Pathways by Exercise Training in Patients With Chronic Obstructive Pulmonary Disease), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Activation of Regenerative Pathways by Exercise Training in Patients With Chronic Obstructive Pulmonary Disease
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
backgroundExercise is a cornerstone of chronic obstructive pulmonary disease (COPD) management and improves quality of life, exercise capacity, exacerbation frequency and survival. However, the physiological mechanisms underlying these effects remain unclear. Small airway dysfunction and airway remodeling may not be adequately captured by spirometry, whereas impulse oscillometry (IOS) may be more sensitive to changes in respiratory mechanics. We hypothesized that an exercise intervention designed to engage the peripheral lung may promote adaptive, and potentially, reparative processes in COPD. The aim of the study was to evaluate changes in lung function after a 12-week exercise intervention, focusing on small airway-related measures assessed by IOS. Secondary aims were to assess changes in exercise capacity and patient-reported outcomes.
methodsIn this prospective multicenter single-arm non-randomized intervention study, participants with COPD (n = 62) completed a 12-week supervised, individually tailored moderate-intensity aerobic- and muscle-strengthening exercise program (3 sessions/week). Lung function (spirometry, body plethysmography, diffusing capacity and IOS), exercise capacity (6-minut walk test, 1-minute sit-to-stand) and symptom burden (CAT, CCQ, mMRC) were assessed before and after the intervention.
resultsSignificant improvements were observed in IOS measures including R5 (median paired difference (Δ) = - 0.75 z-score, p = 0.001), R5-R20 (Δ=-0.18 z-score, p = 0.007), Fres (Δ=-0.33 Hz, p = 0.022) and AX (Δ=-0.05 kPa·s⁻¹, p = 0.042). No significant changes were observed in spirometry or lung volumes, except for a small increase in FVC (Δ = 0.12 z-score, p = 0.027). Exercise capacity improved (Δ6MWT = + 15 m, p = 0.002; Δ1STS = + 3 repetitions, p < 0.0001), while symptom burden decreased (ΔCAT = - 1.0, p = 0.014; ΔCCQ = - 0.1, p = 0.011).
conclusionsIOS measures improved after the exercise intervention, suggesting physiological adaptations beyond skeletal muscle conditioning that resulted in improved airway mechanics and ventilation distribution in the peripheral lung, while other lung function measures remained largely unchanged. CLINICAL
trial registrationClinicalTrials.gov ID NCT06335992 (Registration date 2024-03-28).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.