Evidence map›Paper›PMID 42864661›Full record

ReviewJournal of translational medicine2026

From equilibrium to dynamic metabolic imaging: the evolving role of magnetic resonance spectroscopic imaging in neurodegenerative disorders.

Marta M Pokotylo, Josh P Peters, Aaron Diercks, Farhad Haj Mohamad, Norbert Brüggemann, Andrey N Pravdivtsev, Jan-Bernd Hövener, Jannik Prasuhn

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marta M PokotyloDepartment of Neurology, Section of Movement Disorders, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany.
Josh P PetersSection of Biomedical Imaging, Molecular Imaging North Competence Center, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel University, Kiel, Germany.
Aaron DiercksSection of Biomedical Imaging, Molecular Imaging North Competence Center, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel University, Kiel, Germany.
Farhad Haj MohamadSection of Biomedical Imaging, Molecular Imaging North Competence Center, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel University, Kiel, Germany.
Norbert BrüggemannDepartment of Neurology, Section of Movement Disorders, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany.
Andrey N PravdivtsevSection of Biomedical Imaging, Molecular Imaging North Competence Center, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel University, Kiel, Germany.
Jan-Bernd HövenerSection of Biomedical Imaging, Molecular Imaging North Competence Center, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel University, Kiel, Germany.
Jannik PrasuhnDepartment of Neurology, Section of Movement Disorders, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany. j.prasuhn@uni-luebeck.de.

Funding

DFG 555951950, 527469039DFG HO-4602/2-2, HO-4602/3, EXC2167, FOR5042, TRR287Else Kröner-Fresenius-Stiftung 2023_EKEA.168European Regional Development Fund (ERDF) European Regional Development Fund (ERDF)German Ministry of Education and Research 03WIR6208A hyperquantHeisenberg DFG 565789098Zukunftsprogramm Wirtschaft of Schleswig-Holstein Project no. 122-09-053
6 · The paper itself

Abstract

backgroundDysregulated brain metabolism is increasingly recognized to play a significant role in the development and progression of neurodegenerative diseases (NDDs). Conventional imaging methods, such as positron emission tomography (PET), are limited to assessing tracer uptake and offer no insight into its downstream metabolic fate. Additionally, PET provides no insight into dynamic metabolic fluxes and turnover, which reflect biochemical processes. In contrast, magnetic resonance spectroscopy and spectroscopic imaging MRS(I) allow non-invasive, spatially resolved in vivo investigation of specific metabolites, without the use of radioactive tracers. MAIN BODY:

conclusionDynamic MRS(I) provides a promising foundation for in vivo brain metabolism investigation in NDDs, offering mechanistic insights into metabolic fluxes, reprogramming, and bottlenecks. Although dynamic MRS(I) is limited to a few research institutions, ongoing technical and methodological advances are improving its feasibility, biochemical specificity, and broader implementation. Standardized and harmonized acquisition, reconstruction, and preprocessing protocols are necessary to enable broad clinical implementation of these approaches. Nevertheless, the shift from static to dynamic MRS(I) has great potential to advance biomarker and diagnostic tool development, patient stratification, and longitudinal disease monitoring in NDDs, provided that current challenges and limitations are sufficiently addressed.

Indexed as

Magnetic Resonance ImagingNeurodegenerative DiseasesAnimalsHumansMagnetic Resonance SpectroscopyHyperpolarizationMagnetic resonance spectroscopic imaging (MRSI)Magnetic resonance spectroscopy (MRS)Metabolic modelingNeurodegenerative diseases

Identifiers

PMID42864661
PMCPMC13659993

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.