Evidence map›Paper›PMID 42864634›Full record

ArticleBMC biology2026

Foxn1 regulates epidermal structure, redox balance, and age related changes.

Sylwia Machcinska-Zielinska, Marta Kopcewicz, Joanna Wisniewska, Karla Valdivieso, Mikolaj Ogrodnik, Katarzyna Walendzik, Barbara Gawronska-Kozak

Abstract read
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In one paragraph

Article in BMC biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sylwia Machcinska-ZielinskaInLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Trylińskiego 18, Olsztyn, 10-683, Poland. s.machcinska@pan.olsztyn.pl.ORCID https://orcid.org/0000-0003-3892-4519
Marta KopcewiczInLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Trylińskiego 18, Olsztyn, 10-683, Poland.
Joanna WisniewskaInLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Trylińskiego 18, Olsztyn, 10-683, Poland.
Karla ValdiviesoLudwig Boltzmann Institute for Traumatology in AUVA Research Center, Vienna, Austria.
Mikolaj OgrodnikLudwig Boltzmann Institute for Traumatology in AUVA Research Center, Vienna, Austria.
Katarzyna WalendzikInLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Trylińskiego 18, Olsztyn, 10-683, Poland.
Barbara Gawronska-KozakInLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Trylińskiego 18, Olsztyn, 10-683, Poland.

Funding

Narodowym Centrum Nauki 2023/07/X/NZ4/00537
6 · The paper itself

Abstract

backgroundSkin aging is a complex process, marked by structural decline, functional impairment, and diminished regenerative capacity. In this study, we shine a spotlight on the transcription factor Foxn1 and its pivotal role in modulating age-related changes in skin architecture and redox homeostasis. Using a murine model across three life stages (young - 20-days-old, middle-age - 1-year-old, old - 2-year-old), we compared wild-type (Foxn1

resultsOur findings reveal a striking impact of Foxn1 on skin morphology: Foxn1

conclusionsTogether, these results position Foxn1 as one of key regulators of skin homeostasis and reveal its potential role in skin aging processes.

Indexed as

AgingEpidermisForkhead Transcription FactorsSkin AgingAnimalsMiceMice, KnockoutOxidation-ReductionForkhead Transcription FactorsWhn proteinAgingFoxn1RedoxSkin

Identifiers

PMID42864634
PMCPMC13660126

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.