Evidence map›Paper›PMID 42864571›Full record

ArticleGeroScience2026

Reduced structural connectivity in age-related hearing loss aligns with the sensory deprivation theory.

Jordi H C Boons, Alberto De Luca, Gertjan Dingemanse, Elisabeth J Vinke, Bernd Kremer, Meike W Vernooij, André Goedegebure

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Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jordi H C BoonsDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. j.boons@erasmusmc.nl.ORCID http://orcid.org/0009-0001-8710-6427
Alberto De LucaImage Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
Gertjan DingemanseDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Elisabeth J VinkeDepartment of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Bernd KremerDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Meike W VernooijDepartment of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
André GoedegebureDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related hearing loss (ARHL) may contribute to cognitive decline through structural degeneration and brain reorganization, as posited by the sensory deprivation theory. These processes can be characterized by topological changes, such as strengthening and weakening of structural connections between brain regions. Stronger connections are more relevant to reorganization, as reorganization is thought to support speech processing by recruiting additional brain networks as a compensatory mechanism. We investigated connectivity changes associated with ARHL to improve the understanding of the sensory deprivation theory. Similar to the lateralization of speech processing, we hypothesized that structural reorganization associated with ARHL would be most evident in the left hemisphere. We assessed whole-brain structural connectivity using 1.5 Tesla diffusion-weighted MRI and structural T1 images in 2402 participants (median age = 66.1 years, females = 54.7%) from the population-based Rotterdam Study. Pure-tone audiometry was performed, and pure-tone averages (PTAs), for different frequency ranges including PTA

Indexed as

Age-related hearing lossNetwork analysisPopulation-basedStructural connectivity

Identifiers

PMID42864571

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.