Evidence map›Paper›PMID 42864556›Full record

Observational studyTranslational stroke research2026

Long-Term Quantitative MRI and Quality-of-Life After Endovascular Therapy in Acute Ischemic Stroke - A MR CLEAN-NO IV Substudy.

Praneeta R Konduri, Dimitrios Karkalousos, Alexandra de Sitter, Manon Kappelhof, Maarten M H Lahr, Chi P Nguyen, Aad van der Lugt, Yvo B Roos, Jonathan M Coutinho, Henk A Marquering and 4 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Translational stroke research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Praneeta R KonduriDepartment of Biomedical Engineering and Physics, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Dimitrios KarkalousosDepartment of Biomedical Engineering and Physics, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Alexandra de SitterDepartment of Radiology and Nuclear Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Manon KappelhofDepartment of Radiology and Nuclear Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Maarten M H LahrDepartment of Epidemiology, Health Technology Assessment unit, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Chi P NguyenDepartment of Epidemiology, Health Technology Assessment unit, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Aad van der LugtDepartment of Radiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Yvo B RoosDepartment of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Jonathan M CoutinhoDepartment of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Henk A MarqueringDepartment of Biomedical Engineering and Physics, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Charles B L M MajoieDepartment of Radiology and Nuclear Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Bart J EmmerDepartment of Radiology and Nuclear Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Luka C LiebrandDepartment of Biomedical Engineering and Physics, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Matthan W A CaanDepartment of Biomedical Engineering and Physics, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands. m.w.a.caan@amsterdamumc.nl.ORCID http://orcid.org/0000-0002-5162-8880

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to explore the long-term evolution of endovascular treatment after acute ischemic stroke (AIS) using quantitative MRI, and its relationship with quality of life (QoL). In this long-term substudy of patients from the MR CLEAN-NO IV trial, patients were included who received 24-hour post-stroke MRI and were functionally independent 90 days after stroke onset. Patients underwent a quantitative MRI exam three years after stroke onset to measure focal volume loss, myelin damage, iron deposition, and atrophy within and around the ischemic lesion seen on 24-hour-MRI, in addition to a QoL assessment. Bayesian statistical analyses were used to assess MRI measures lateralized to the ipsilateral hemisphere and to evaluate the relationship of these measures with baseline and treatment characteristics along with QoL. The Bayes Factor (BF) reflected moderate, strong or very strong evidence (BF = 3.0;20;1.5⋅10

Indexed as

Brain IschemiaEndovascular ProceduresIschemic StrokeMagnetic Resonance ImagingQuality of LifeStrokeAgedBrainFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicTreatment OutcomeAcute ischemic strokeBrainLong-term follow-upQuality-of-lifeQuantitative MRI

Identifiers

PMID42864556
PMCPMC13658416

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.