Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Cheng GaoHealth Informatics Institute, University of South Florida, Tampa, FL, USA.
Lei YuRush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-0237-8758
Jingyun YangRush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Francine GrodsteinRush Alzheimer's Disease Center & Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
Julie A SchneiderRush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9482-1752
Lisa L BarnesRush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Philip L De JagerCenter for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8057-2505
Genome-wide Profiling of Brain DNA Hydroxymethylome in Alzheimer’s DiseaseRF1AG052476 · NIA · UNIVERSITY OF FLORIDA · PI BENNETT, DAVID ALAN, JIN, PENG · 2016 to 2019
$4.1M
Epigenetic Determinants of Major Depression: a Monozygotic Discordant TwinStudyR01MH097018 · NIMH · UNIVERSITY OF FLORIDA · PI ZHAO, JINYING · 2013 to 2017
$3.3M
Telomere attrition and diabetes risk in American IndiansR01DK091369 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HE, JIANG · 2011 to 2014
$1.1M
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK091369U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH097018U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) P30AG10161U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) P30AG72975U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG15819U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG17917U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) RF1AG052476
6 · The paper itself
Abstract
DNA methylation (DNAm) plays a critical role in Alzheimer's disease (AD). Previous epigenome-wide association studies using 450K arrays captured limited CpG coverage and often focused on a single neuropathological measure. Here we profiled DNAm in 1,250 postmortem prefrontal cortex samples from the Rush Alzheimer's Disease cohorts using the Infinium MethylationEPIC v2 array (~930,000 CpGs) and performed epigenome-wide association studies of multiple neuropathologic measures, including AD diagnosis, amyloid-β and tau tangles. We identified 107 differentially methylated probes associated with AD neuropathology, 38 of which were replicated in an independent cohort (n = 139). DNAm also partially mediated the effect of APOE genotype on AD diagnosis (proportion mediated: 8.6%, P = 2 × 10
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Brain DNA methylation, APOE genotype and Alzheimer's disease neuropathology in a large postmortem cohort. · full record | OpenQuestion