ArticleSurgical endoscopy2026
TRIDENT: inTRaoperative Imaging DEvice based on endogeNous opTical properties to evaluate bowel oxygenation in left-sided colorectal resections. Observational first-in-human pilot safety trial.
Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05973227 (InTRaoperative Imaging DEvice Based on endogeNous opTical Properties to Evaluate Bowel Oxygenation in Colorectal Resections), which is not on this map. Not yet cited in PubMed.
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InTRaoperative Imaging DEvice Based on endogeNous opTical Properties to Evaluate Bowel Oxygenation in Colorectal Resections: Observational First-in-human Pilot Safety Trial -TRIDENT-
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10 authors.
Funding
Abstract
backgroundAdequate tissue oxygenation at the anastomotic site is a key determinant of healing after colorectal surgery. Current intraoperative imaging technologies aimed at assessing bowel perfusion present several limitations, including the need for exogenous contrast agents, limited quantification capabilities, or suboptimal integration within the surgical workflow. Single Snapshot Imaging of Optical Properties (SSOP) is a contrast-free optical imaging technology capable of quantifying tissue oxygen saturation (StO
methodsIn this prospective, single-center feasibility trial, patients undergoing elective left-sided colorectal resection with primary anastomosis were enrolled. After bowel exteriorization, surgeons identified the intended proximal transection line based on their clinical judgement. SSOP imaging was then performed to quantify tissue oxygenation along the exposed colon segment before resection. The primary endpoints of the study were assessing the overall intraoperative safety and workflow feasibility of the Trident system. The secondary endpoint was to obtain wide-field oxygen saturation (StO
resultsBetween September 2023 and April 2024, 10 patients were enrolled (8 males; mean age 65.5 ± 11.8 years; mean BMI 27.5 ± 4.6 kg/m
conclusionsThis first-in-human study demonstrated that SSOP imaging using Trident is safe, feasible, and compatible with standard surgical workflow during left-sided colorectal resections. The ability to provide real-time, quantitative, contrast-free mapping of bowel oxygenation may represent a promising tool for intraoperative perfusion assessment. Larger prospective studies are needed to evaluate whether SSOP-guided surgery can improve anastomotic outcomes (NCT05973227).
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