Evidence map›Paper›PMID 42864399›Full record

ArticleNature immunology2026

Zbtb44-mediated transcriptional repression critically regulates colonic inflammation.

Mahesh Kathania, Desh Raj, Thirupugal Govindarajan, Dinesh Ravindra Raju, Amit K Verma, Anirban Roy, Risha Mathur, Jenna Woody, Amir Kumar Singh, Chul Ahn and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mahesh KathaniaDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Desh RajDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Thirupugal GovindarajanDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-2660-9730
Dinesh Ravindra RajuEugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Amit K VermaDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Anirban RoyDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Risha MathurDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Jenna WoodyDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0009-0001-6764-691X
Amir Kumar SinghDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Chul AhnHarold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.
Suraj PatelDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Jianyi YinDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Andrew LemoffDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Arianne L TheissDivision of Gastroenterology and Hepatology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-2862-0933
Chao XingEugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-1838-0502
Tuoqi WuDepartment of Immunology, UT Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-4003-1034
Ezra BursteinDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-4341-6367
K VenuprasadDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA. venuprasad.poojary@UTSouthwestern.edu.ORCID http://orcid.org/0000-0001-8986-9092

Funding

U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01-CA266072U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01-CA282143U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01-AI155786
6 · The paper itself

Abstract

The regulatory mechanisms that maintain colonic immune homeostasis remain incompletely understood. Here we show that genetic deletion of Zbtb44, a previously uncharacterized member of the ZBTB transcription factor family, leads to spontaneous colitis and rectal prolapse. Zbtb44

Identifiers

PMID42864399

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.