ArticleNature communications2026
BRWD1 directs B cell epigenetic states required for germinal center initiation, maintenance and function.
Nathaniel E Wright, Domenick E Kennedy, Junting Ai, Margaret L Veselits, Mary Attaway, Young Me Yoon, Madeleine S Durkee, Jacob Veselits, Mark Maienschein-Cline, Malay Mandal and 1 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Domenick E KennedyDepartment of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, USA.
Junting AiDepartment of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, USA.
Young Me YoonDepartment of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, USA.
Jacob VeselitsDepartment of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, USA.
Malay MandalDepartment of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, USA. mmandal@bsd.uchicago.edu.ORCID http://orcid.org/0000-0002-0451-3896 Marcus R ClarkDepartment of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, USA. mclark@uchicago.edu.ORCID http://orcid.org/0000-0003-4747-0387 Funding
Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7MMEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1MRole of CXCR4 in immunoglobulin light chain recombinationR01AI150860 · NIAID · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY, MANDAL, MALAY · 2021 to 2025
$2.9MThe epigenetic reader BRWD1 in peripheral adaptive immunityR01AI143778 · NIAID · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 2019 to 2023
$2.4MThe role of BRWD1 to establish epigenetic states for germinal center initiation, maintenance, and exitF30AI174324 · NIAID · UNIVERSITY OF CHICAGO · PI Nathaniel Edwin Wright · 2023 to 2026
$216kNCATS NIH HHS UL1 TR002003NIAID NIH HHS F30 AI174324NIAID NIH HHS R01 AI143778NIAID NIH HHS R01 AI150860NIGMS NIH HHS T32 GM007281U.S. Department of Health & Human Services | National Institutes of Health (NIH) F30 AI174324U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01 AI143778U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01 AI150860U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32 GM007281U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR002003
6 · The paper itselfAbstract
Germinal center (GC) B cells, differentiated from follicular B cells following activation, can be assigned to light zone (LZ), dark zone proliferation (DZp), or dark zone differentiation (DZd) states, as compartmentalized by the antagonistic molecular programs of selection, proliferation, and somatic hypermutation respectively. In the bone marrow, an epigenetic reader, BRWD1, orchestrates the sequential stages of B cell progenitor proliferation and B cell receptor recombination. Here, we analyze mice with a conditional knockout of Brwd1 in follicular B cells (Cd23
Indexed as
B-LymphocytesEpigenesis, GeneticGerminal CenterAnimalsCell DifferentiationCell ProliferationLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutSomatic Hypermutation, Immunoglobulin
Identifiers
PMID42864370
PMCPMC13658786
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