Evidence map›Paper›PMID 42864358›Full record

ArticleNpj viruses2025

High host specificity of alphacoronaviruses in Nearctic, insectivorous bats.

Jonathon D Kotwa, Arkadeb Bhuinya, Winfield Yim, Giulia Gallo, Pahul Singh, Qiang Liu, Anil Kumar, Emily Chien, Aaron Hou, Hsien-Yao Chee and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Npj viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jonathon D KotwaSunnybrook Research Institute, Toronto, ON, Canada.
Arkadeb BhuinyaVaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada.
Winfield YimSunnybrook Research Institute, Toronto, ON, Canada.
Giulia GalloThe Pirbright Institute, Guildford, Surrey, UK.
Pahul SinghVaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada.
Qiang LiuVaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada.
Anil KumarDepartment of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada.
Emily ChienSunnybrook Research Institute, Toronto, ON, Canada.
Aaron HouSunnybrook Research Institute, Toronto, ON, Canada.
Hsien-Yao CheeSunnybrook Research Institute, Toronto, ON, Canada.
Juliette Blais-SavoieSunnybrook Research Institute, Toronto, ON, Canada.
Lily YipSunnybrook Research Institute, Toronto, ON, Canada.
Valerie Von ZubenWildlife Research and Monitoring Section, Ontario Ministry of Natural Resources and Forestry, Peterborough, ON, Canada.
K Aidan WoutersDepartment of Biology, Carleton University, Ottawa, ON, Canada.
Vikram MisraDepartment of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Oliver LungNational Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB, Canada.
Dalan BaileyThe Pirbright Institute, Guildford, Surrey, UK.
Finlay MaguireFaculty of Computer Science, Dalhousie University, Halifax, NS, Canada.
Arinjay BanerjeeVaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada.
Samira MubarekaSunnybrook Research Institute, Toronto, ON, Canada. samira.mubareka@sunnybrook.ca.
Christina M DavyWildlife Research and Monitoring Section, Ontario Ministry of Natural Resources and Forestry, Peterborough, ON, Canada.

Funding

CIHR MM1174925CIHR PTT-192089Natural Sciences and Engineering Research Council of Canada RGPIN-2020-06199Natural Sciences and Engineering Research Council of Canada RGPIN-2022-03010
6 · The paper itself

Abstract

Bats are reservoir hosts for a number of coronaviruses, some of which may pose spillover risks for humans and other animals. We detected two alphacoronaviruses in big brown bats (Eptesicus fuscus) and little brown myotis (Myotis lucifugus) in Ontario, Canada. These viruses are closely related to other coronaviruses circulating in bats in North America and also distantly related to human and swine coronaviruses. We found high similarity in the receptor-binding domain (RBD) in viruses derived from the same species of bat, but markedly lower in those derived from other species. We also functionally characterized the accessory protein ORF3 finding that ORF3 inhibited both IFNβ production and signaling. Our study provides insights into coronavirus diversity in bats in a previously under-sampled region. This work provides a baseline for in-depth surveillance to characterize the transmission dynamics of endemic coronaviruses in free-ranging wildlife, and for exploring the evolutionary relationships between coronaviruses and their hosts.

Identifiers

PMID42864358

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.