ArticleNature communications2026
Chronic loneliness and isolation phenotypes and physical and mental health in older adults.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Chronic loneliness and isolation phenotypes and physical and mental health in older adults.Nature communications · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Chronic social deficits (persistent feelings of being lonely or isolated) have been linked to premature mortality, yet the underlying physical and mental pathways remain unclear. This study used data from 4,090 older adults in the English Longitudinal Study of Ageing, a longitudinal panel study. Using outcome-wide analyses, we assessed how the chronicity of social deficits was associated with 17 health outcomes across physical, mental, cognitive and behavioural health domains. Regression models showed that chronic loneliness was longitudinally associated with increased risks of worse general health, functional capacity, and mental wellbeing, and more unhealthy behaviours. Chronic isolation and onset of isolation were associated with lower quality of life, whereas isolation remission was positively related to enhanced mental wellbeing and cognition compared to no isolation. Findings suggest an association between chronicity of loneliness and adverse health outcomes, highlighting chronic social deficits as an important correlate of healthy ageing.
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Registered trials
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