ArticleNature communications2026
A programmable organosulfate platform for concurrent molecular sequence and topology control.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal-organic frameworks achieve structural complexity without deterministic sequence control. Conversely, biological macromolecules encode molecular information with extraordinary precision, yet provide limited access to discrete void-bearing topological complexity. Bridging these paradigms requires a programmable strategy capable of simultaneously defining molecular sequence and topology within a unified synthetic framework. Here we introduce a programmable platform that achieves this dual control. Iterative SuFEx-based homologation, coupled with controlled annulation, enables precise sequence definition and topological specification. Incorporation of a trifunctional scaffold permits access to bicyclic and cage-like molecular architectures with defined connectivities. Physicochemical analyses reveal that encoded sequence and topology dictate thermal stability and hydrodynamic behavior. Extension to polysulfate networks further demonstrates topology-dependent gelation, establishing programmable organosulfates as a versatile platform for constructing information-rich molecular systems and functional soft matter.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.