Evidence map›Paper›PMID 42864332›Full record

ArticleNature communications2026

The hijacking of a wheat Exo70-like protein by a fungal pathogen triggers disease.

Gurminder Singh, Katherine L D Running, Zengcui Zhang, Sudeshi Seneviratne, Krishna Acharya, Tiana M Roth, Amanda R Peters Haugrud, Agnes Szabo-Hever, Pooja Kumari, Phillip E McClean and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gurminder SinghDepartment of Plant Sciences, North Dakota State University, Fargo, ND, USA.ORCID http://orcid.org/0000-0002-2637-7282
Katherine L D RunningDepartment of Plant Sciences, North Dakota State University, Fargo, ND, USA.ORCID http://orcid.org/0000-0001-7577-1123
Zengcui ZhangUSDA-ARS, Edward T. Schafer Agricultural Research Center, Fargo, ND, USA.ORCID http://orcid.org/0000-0002-0831-4069
Sudeshi SeneviratneDepartment of Plant Sciences, North Dakota State University, Fargo, ND, USA.ORCID http://orcid.org/0000-0001-9747-2618
Krishna AcharyaDepartment of Plant Sciences, North Dakota State University, Fargo, ND, USA.ORCID http://orcid.org/0000-0003-0538-1028
Tiana M RothDepartment of Plant Sciences, North Dakota State University, Fargo, ND, USA.ORCID http://orcid.org/0000-0002-6350-4543
Amanda R Peters HaugrudUSDA-ARS, Edward T. Schafer Agricultural Research Center, Fargo, ND, USA.ORCID http://orcid.org/0000-0002-8762-0688
Agnes Szabo-HeverDepartment of Plant Sciences, North Dakota State University, Fargo, ND, USA.ORCID http://orcid.org/0000-0003-3392-6646
Pooja KumariDepartment of Plant Sciences, North Dakota State University, Fargo, ND, USA.
Phillip E McCleanDepartment of Plant Sciences, North Dakota State University, Fargo, ND, USA.ORCID http://orcid.org/0000-0002-4809-0864
Zhaohui LiuDepartment of Plant Pathology, North Dakota State University, Fargo, ND, USA.ORCID http://orcid.org/0000-0002-8106-9186
Shengming YangUSDA-ARS, Edward T. Schafer Agricultural Research Center, Fargo, ND, USA.ORCID http://orcid.org/0000-0002-4558-8448
Justin D FarisUSDA-ARS, Edward T. Schafer Agricultural Research Center, Fargo, ND, USA. justin.faris@usda.gov.ORCID http://orcid.org/0000-0002-9653-3287

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tan spot is an economically important fungal disease of wheat that occurs globally. In this necrotrophic pathosystem, pathogen effectors are recognized by wheat genes in an inverse gene-for-gene manner, leading to the hijacking of host defense mechanisms and ultimately disease susceptibility. Here, we identified the tan spot susceptibility gene Tsc2 through positional cloning, mutagenesis, and transgenic complementation. Tsc2 encodes a diverged form of the exocyst subunit Exo70FX15 that localizes to the nucleus and cytoplasm and does not interact directly with the fungal effector. A 21‑nucleotide deletion in Tsc2 occurred in durum wheat more than a century ago and subsequently spread to common wheat through breeding practices, which allowed recognition of the pathogen effector and subsequent hijacking of the host immune system. We demonstrate that elimination of Tsc2 through conventional breeding using a diagnostic marker or disruption of Tsc2 by gene editing can be used to improve tan spot resistance in wheat.

Indexed as

AscomycotaPlant DiseasesPlant ProteinsTriticumDisease ResistanceHost-Pathogen InteractionsPlants, Genetically ModifiedPlant Proteins

Identifiers

PMID42864332
PMCPMC13658248

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.