Evidence map›Paper›PMID 42864331›Full record

ArticleNature communications2026

LGR5-positive fibroblasts orchestrate skin mechanoadaptation through JAK1 modulation.

Qiaoyu Fu, Xi Cheng, Nuo Chen, Yidan Sun, Luwen Xu, Yu Cheng, Chen Wang, Yin Li, Tingting Yu, Yuao Yan and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Qiaoyu Fu *Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xi Cheng *Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Nuo Chen *Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yidan Sun *Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0003-0511-0308
Luwen Xu *Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-8996-0686
Yu ChengDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen WangDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yin LiShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Tingting YuShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Yuao YanShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Wenwan ZhangShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Yu BuShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Lifang LeiShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Yining ChenShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Zhen LiShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Peiying ZhuShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Caibing WangShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Liang ZhangShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. zhangliang01@sibs.ac.cn.ORCID http://orcid.org/0000-0003-4396-9199
Caiyue LiuDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yueyue1888@hotmail.com.ORCID http://orcid.org/0000-0002-8141-0380
Qingfeng LiDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. dr.liqingfeng@shsmu.edu.cn.ORCID http://orcid.org/0000-0001-7822-618X

Funding

China Postdoctoral Science Foundation 2018M630449Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2022YFA0807300National Natural Science Foundation of China (National Science Foundation of China) 2571345, 32070730National Natural Science Foundation of China (National Science Foundation of China) 82072191, 82372534, 82572899National Natural Science Foundation of China (National Science Foundation of China) 82361138568Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 22MC1940300Shanghai Science and Technology Development Foundation (Shanghai Science and Technology Development Fund) KJH-YGJC-20250B02
6 · The paper itself

Abstract

Mechanical adaptation is a fundamental yet poorly understood process in stromal tissue biology. Here, we identify a population of LGR5

Indexed as

FibroblastsJanus Kinase 1Receptors, G-Protein-CoupledSkinAdaptation, PhysiologicalAnimalsDermisExtracellular MatrixFemaleHumansMechanotransduction, CellularMiceSignal TransductionStress, MechanicalJak1 protein, mouseJanus Kinase 1Receptors, G-Protein-Coupled

Identifiers

PMID42864331
PMCPMC13658777

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.