Evidence map›Paper›PMID 42863561›Full record

ArticleToxicology2026

Perturbation of metabolic pathways associated with exposure of human renal proximal tubular cells to nephrotoxic pollutants and drugs.

Lawrence H Lash, Xin Hu, Patricia A Mathieu, Mary D Gargano, Dean P Jones, Rita Rosati, Paul M Stemmer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lawrence H LashDepartment of Pharmacology, Wayne State University School of Medicine, Detroit, MI, 48201, USA. Electronic address: l.h.lash@wayne.edu.
Xin HuGangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, 30322, USA; Division of Pulmonary Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Patricia A MathieuDepartment of Pharmacology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Mary D GarganoDepartment of Pharmacology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Dean P JonesDivision of Pulmonary Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Rita RosatiInstitute of Environmental Health Sciences, Wayne State University, Detroit, MI, 48202, USA.
Paul M StemmerInstitute of Environmental Health Sciences, Wayne State University, Detroit, MI, 48202, USA.

Funding

Pilot Project ProgramP30ES020957 · NIEHS · WAYNE STATE UNIVERSITY · PI RUNGE-MORRIS, MELISSA A · 2014 to 2021
$10.1M
Mitochondrial and Cellular Biomarkers of Renal Injury from Environmental and Therapeutic AgentsR01ES031584 · NIEHS · WAYNE STATE UNIVERSITY · PI LASH, LAWRENCE H. · 2021 to 2024
$1.5M
NIEHS NIH HHS P30 ES020957NIEHS NIH HHS R01 ES031584
6 · The paper itself

Abstract

Mammalian kidneys, although exposed to a diverse array of environmental pollutants and commonly used drugs that are dose-limited by nephrotoxicity, have a significant but limited capacity for repair and regeneration. Primary cultures of human proximal tubular (hPT) cells were used to investigate the cellular response to exposures to one of two environmental toxicants (mercuric chloride [HgCl

Indexed as

Acute kidney injuryMercuric chlorideMetabolic reprogrammingNephrotoxic drugsS-(1,2-dichlorovinyl)-L-cysteine

Identifiers

PMID42863561
PMCPMC13690044

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.