Baicalin modulates endoplasmic reticulum-Golgi homeostasis via targeting ATF6-GBF1 axis to alleviate copper-induced nephrotoxicity in duck.

Hongyu Shang, Wei Tang, Xueyan Dai, Xiaona Gao, Guoliang Hu, Huabin Cao, Chenghong Xing, Fan Yang

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Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Hongyu ShangJiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Economic and Technological Development District, No. 1101 Zhimin Avenue, Nanchang, Jiangxi, 330045, PR China.

Wei TangJiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Economic and Technological Development District, No. 1101 Zhimin Avenue, Nanchang, Jiangxi, 330045, PR China.

Xueyan DaiJiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Economic and Technological Development District, No. 1101 Zhimin Avenue, Nanchang, Jiangxi, 330045, PR China.

Xiaona GaoJiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Economic and Technological Development District, No. 1101 Zhimin Avenue, Nanchang, Jiangxi, 330045, PR China.

Guoliang HuJiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Economic and Technological Development District, No. 1101 Zhimin Avenue, Nanchang, Jiangxi, 330045, PR China.

Huabin CaoJiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Economic and Technological Development District, No. 1101 Zhimin Avenue, Nanchang, Jiangxi, 330045, PR China.

Chenghong XingJiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Economic and Technological Development District, No. 1101 Zhimin Avenue, Nanchang, Jiangxi, 330045, PR China.

Fan YangJiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Economic and Technological Development District, No. 1101 Zhimin Avenue, Nanchang, Jiangxi, 330045, PR China. Electronic address: yfan@jxau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper (Cu) exposure caused by environmental contamination or dietary imbalance poses a potential threat to poultry health by inducing renal dysfunction and disrupting cellular homeostasis. Baicalin (BA), a natural flavonoid with antioxidant and anti-inflammatory properties, has shown renoprotective potential. However, whether and how BA alleviates Cu-induced nephrotoxicity remains unclear. Disruption of endoplasmic reticulum (ER)-Golgi trafficking impairs cellular homeostasis and may contribute to renal injury, but its role in Cu-induced kidney damage has not been fully defined. In this study, using duck in vivo and in vitro Cu exposure models, we found that Cu downregulated the Golgi structural protein GBF1 and disrupted ER-Golgi trafficking, leading to Golgi fragmentation, ER swelling, and ER stress activation via ATF6. Functional assays revealed that GBF1 knockdown further decreased the expression of Golgi structural and trafficking-related proteins and exacerbated ER stress, whereas ATF6 silencing partially reversed these molecular alterations. Moreover, our results provide evidence that BA can stably bind to ATF6, inhibit its activation and proteolytic cleavage, restore the expression of Golgi and trafficking-related proteins, and reduce ER stress, thereby maintaining organelle homeostasis. In summary, our results identify the GBF1-ATF6 axis as a key pathway in Cu-induced ER-Golgi dysregulation and nephrotoxicity, and provide mechanistic insight into the protective role of BA in restoring subcellular homeostasis.

Indexed as

BaicalinCopperDuckER-Golgi transportNephrotoxicity

Identifiers

PMID42863176

DOI10.1016/j.psj.2026.107914

PMCPMC13682011

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