Evidence map›Paper›PMID 42862624›Full record

ArticleeLife2026

Synaptic connectome of a neurosecretory network in the

Theresa H McKim, Jayati Gera, Ariana J Gayban, Kevin Christie, Joel Shin, Nils Reinhard, Giulia Manoli, Selina Hilpert, Patrick Callaerts, Floris van Breugel and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Theresa H McKimIntegrative Neuroscience Program, University of Nevada Reno, Reno, United States.ORCID https://orcid.org/0000-0002-8501-6487
Jayati GeraNeurobiology and Genetics, Theodor-Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0002-4744-1546
Ariana J GaybanIntegrative Neuroscience Program, University of Nevada Reno, Reno, United States.
Kevin ChristieIntegrative Neuroscience Program, University of Nevada Reno, Reno, United States.ORCID https://orcid.org/0000-0002-3730-3617
Joel ShinDepartment of Biochemistry and Molecular Biology, University of Nevada Reno, Reno, United States.
Nils ReinhardNeurobiology and Genetics, Theodor-Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0002-7989-7150
Giulia ManoliNeurobiology and Genetics, Theodor-Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0001-5954-5919
Selina HilpertNeurobiology and Genetics, Theodor-Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany.
Patrick CallaertsDepartment of Human Genetics, KU Leuven, Leuven, Belgium.
Floris van BreugelIntegrative Neuroscience Program, University of Nevada Reno, Reno, United States.ORCID https://orcid.org/0000-0001-6538-7179
Charlotte Helfrich-FörsterNeurobiology and Genetics, Theodor-Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0002-0859-9092
Meet ZandawalaIntegrative Neuroscience Program, University of Nevada Reno, Reno, United States.ORCID https://orcid.org/0000-0001-6498-2208

Funding

Outreach/Diversity/Pipeline ProjectP20GM103440 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Julia Petereit · 2012 to 2026
$58.0M
Dissemination of FlyWire, A Whole-Brain Connectomics ResourceU24NS126935 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2022 to 2026
$5.6M
Crowdsourcing the Fly ConnectomeRF1MH117815 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA, SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$3.3M
The Functional Role and Neural Basis of Rapid Turns in Olfactory Search BehaviorR01NS136988 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Bingni Wen Brunton, Michael H Dickinson · 2024 to 2026
$3.3M
Automating whole brain connectomics: development, validation, and application of an open toolkitRF1MH120679 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOCK, DAVI · 2019 to 2019
$1.9M
Deutsche Forschungsgemeinschaft FO 207/16-1Deutsche Forschungsgemeinschaft FO 207/21Deutsche Forschungsgemeinschaft INST 93/809-1 FUGGDeutsche Forschungsgemeinschaft ZA1296/1-1Fonds Wetenschappelijk Onderzoek G0ASQ25NNIGMS NIH HHS GM103440NIGMS NIH HHS P20 GM103440NIMH NIH HHS RF1 MH117815NIMH NIH HHS RF1 MH120679NINDS NIH HHS 1R01NS136988NINDS NIH HHS R01 NS136988NINDS NIH HHS U24 NS126935
6 · The paper itself

Abstract

Hormones mediate inter-organ signaling, which is crucial in orchestrating diverse behaviors and physiological processes, including sleep and activity, feeding, growth, metabolism, and reproduction. The pars intercerebralis and pars lateralis in insects represent major hubs that contain neurosecretory cells (NSCs) that produce various peptide hormones. To obtain insight into how hormonal signaling is regulated, we have characterized the synaptic connectome of NSCs in the adult

Indexed as

BrainConnectomeDrosophilaDrosophila melanogasterNeurosecretory SystemsSynapsesAnimalsDrosophila ProteinsFemaleInsect HormonesNeuronsDh44 protein, DrosophilaDrosophila ProteinsInsect Hormonesconnectomicsdescending neuronsD. melanogasteregg-layingendocrine signalingneuropeptidesneurosciencetaste

Identifiers

PMID42862624
PMCPMC13657632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.