Evidence map›Paper›PMID 42862516›Full record

ArticleInternational urology and nephrology2026

Multi-omics analyses based identification of therapeutic targets for rapid kidney function decline and chronic kidney disease, a mendelian randomization study.

Lei-Yun Wang, Qiu-Qi Li, Xiang-Yu Yang, Xin-Qi Teng, Lu-Lu Li, Shao-Hui Zhang

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Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Lei-Yun Wang *Department of Pharmacy, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, PR China.
Qiu-Qi Li *Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, 430000, Hubei Province, PR China.
Xiang-Yu Yang *Department of Pharmacy, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, PR China.
Xin-Qi TengDepartment of Pharmacy, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, PR China.
Lu-Lu LiDepartment of Pharmacy, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, PR China. lilulu.zzu@163.com.
Shao-Hui ZhangDepartment of Pharmacy, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, PR China. zshtjmu@hotmail.com.

Funding

Hubei Provincial Natural Science Foundation of China 2026AFB267The Health Commission of Hubei Province Foundation WJ2021M005The Scientific Research Project of Wuhan Municipal Health Commission WZ22C44The Wuhan Pharmaceutical Association Foundation WHPA202302088
6 · The paper itself

Abstract

purposeRapid kidney function decline and chronic kidney disease (CKD) remain significant threats to global health. Currently, there are no effective therapeutic agents capable of reversing progression of CKD. A two-stage Mendelian randomization (MR) study was conducted to uncover causal therapeutic mechanisms of pQTLs during kidney function decline.

methodsExposure data comprised 4,853 distinct proteins and their corresponding protein quantitative trait loci (pQTLs, p < 5×10

resultsA total of 37 proteins (p < 1.03×10

conclusionIGFBP4 and CLMP represent promising therapeutic targets for rapid kidney function decline and CKD. Further investigation is warranted to elucidate the underlying mechanisms and validate their functional roles through larger cohort studies.

Indexed as

Chronic kidney diseaseMendelian randomizationMulti-omicsRapid kidney function declineTherapeutic target

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.