ArticleInternational urology and nephrology2026
Multi-omics analyses based identification of therapeutic targets for rapid kidney function decline and chronic kidney disease, a mendelian randomization study.
Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeRapid kidney function decline and chronic kidney disease (CKD) remain significant threats to global health. Currently, there are no effective therapeutic agents capable of reversing progression of CKD. A two-stage Mendelian randomization (MR) study was conducted to uncover causal therapeutic mechanisms of pQTLs during kidney function decline.
methodsExposure data comprised 4,853 distinct proteins and their corresponding protein quantitative trait loci (pQTLs, p < 5×10
resultsA total of 37 proteins (p < 1.03×10
conclusionIGFBP4 and CLMP represent promising therapeutic targets for rapid kidney function decline and CKD. Further investigation is warranted to elucidate the underlying mechanisms and validate their functional roles through larger cohort studies.
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