Evidence map›Paper›PMID 42862494›Full record

ArticleDiscover nano2026

Copper single-atom carbon dots hydrogel resets oxidative and immune homeostasis for rheumatoid arthritis therapy.

Qian He, Jie Kang, Dan Ma, Yingying Zhang, Xiaorong Linghu, Yipu Han, Meirong Wang, Yirong Yuan, Liyun Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qian He *Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Jie Kang *Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Dan MaShanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Yingying ZhangDepartment of Biomedical Engineering, Shanxi Medical University, Taiyuan, 030001, China.
Xiaorong LinghuDepartment of Biomedical Engineering, Shanxi Medical University, Taiyuan, 030001, China.
Yipu HanDepartment of Biomedical Engineering, Shanxi Medical University, Taiyuan, 030001, China.
Meirong WangDepartment of Biomedical Engineering, Shanxi Medical University, Taiyuan, 030001, China.
Yirong YuanDepartment of Biomedical Engineering, Shanxi Medical University, Taiyuan, 030001, China.
Liyun ZhangShanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China. zhangly@sxbqeh.com.cn.

Funding

National Natural Science Foundation of China 82502195Research and Innovation Team Project for Scientific Breakthroughs at Shanxi Bethune Hospital 2024AOXIANG02Shanxi Province Central Government Guidance Fund for Local Science and Technology Development YDZJSX2024B011Shanxi Province Clinical Theranostics Technology Innovation Center for Immunologic and Rheumatic Diseases CXZX-202302Talent Introduction Research Initiation Fund of Shanxi Bethune Hospital 2022RC04
6 · The paper itself

Abstract

Rheumatoid arthritis pathogenesis is perpetuated by a self-sustaining oxidative stress-immunodysregulation circuit. To address the limitations of conventional antioxidants, including unclear catalytic structures and single catalytic activity, we engineered copper single-atom carbon dots via topological transformation of sodium copper chlorophyllin. Encapsulated within a pH-responsive injectable hydrogel, this system achieves targeted delivery to inflamed joints, where it simultaneously scavenges superoxide anions and hydrogen peroxide, breaking the reactive oxygen species-inflammation cycle. Treatment reprograms macrophage polarization, suppresses pathogenic B-cell infiltration, and mitigates cartilage erosion. By integrating nature-inspired atomic catalysis with intelligent biomaterial engineering, this approach establishes a paradigm for resetting oxidative-immune microenvironments in autoimmune diseases.

Indexed as

Copper single-atom carbon dotsImmune reprogrammingInjectable hydrogelOxidative stressRheumatoid arthritis

Identifiers

PMID42862494
PMCPMC13658670

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.