Evidence map›Paper›PMID 42862459›Full record

ArticleProbiotics and antimicrobial proteins2026

Lacticaseibacillus paracasei SX52-B Isolated from Centenarians' feces: Genomic Analysis and Hypoglycemic Activity Evaluation.

Yueting Zhu, Congjie Ning, Yushan Ding, Weiwen Xiong, Poyu Liao, Guanfu Yang, Jingzhen Wu, Peihua Tang, Xinhe Luo, Lijun Lv and 3 more

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Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Yueting Zhu *Zhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Congjie Ning *Zhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Yushan DingZhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Weiwen XiongZhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Poyu LiaoZhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Guanfu YangZhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Jingzhen WuZhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Peihua TangZhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Xinhe LuoZhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Lijun LvZhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Hui LuoZhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Yi QiZhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China. qiyi7272@gdmu.edu.cn.
Xuemeng LiZhanjiang Key Laboratory of Human Microecology and Clinical Translation Research, The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China. lixuemeng@gdmu.edu.cn.ORCID http://orcid.org/0000-0003-1398-8313

Funding

2023 Innovation Experiment Project for College Students of Guangdong Medical University No. ZZDG0022024 Innovation and Entrepreneurship Education Base Program of Guangdong Medical University No. JDXM2024088Clinical & Basic Science Technology Innovation Project of Guangdong Medical University GDMU1.CJC2025119GuangDong Basic and Applied Basic Research Foundation No.2024A1515140030Special Funds for Economic Development of Marine Economy of Guangdong Province, China No. GDNRC[2022]38the Doctoral Initial Funding of Guangdong Medical University No. 4SG23183Gthe Natural Science Foundation of China No. 82301752the Technology Innovation Strategy Special Foundation of Zhanjiang No. 2023A01005
6 · The paper itself

Abstract

Probiotics have been reported to effectively modulate human glucose metabolism. Here, we aim to isolate and identify Lacticaseibacillus paracasei SX52-B (L. paracasei SX52-B) from the intestines of centenarians, investigate its hypoglycemic properties, and explore the potential molecular mechanisms through integration of genomic analysis. To evaluate the probiotic properties, L. paracasei SX52-B was subjected to growth characteristics, safety and functional tests. Whole-genome sequencing of L. paracasei SX52-B was performed to identify functional genes related to hypoglycemic properties. Genomic annotation was conducted by comparing against databases such as GO, COG, KEGG, and CAZy. Firstly, L. paracasei SX52-B exhibited great biosafety across a series of assays. It could survive in simulated gut microbiota juices, indicating significant tolerance to acidic conditions and bile salts. Moreover, L. paracasei SX52-B showed no hemolytic activity and exhibited antibiotic susceptibility within safe limits. In the acute oral toxicity test of mice, neither adverse reactions nor significant differences in organ indices were detected after they were fed different doses of L. paracasei SX52-B for 28 days. Genomic sequencing and analysis revealed that the genome size of SX52-B is 2,991,568 bp. Through functional annotations, relatively rare carbohydrate metabolism-related genes such as malX (maltose/glucose PTS system EIICB component), tpiA (triosephosphate isomerase) and E5.1.3.15 (glucose-6-phosphate 1-epimerase), were identified in L. paracasei SX52-B, which were rarely detected in common L. paracasei strains. These results suggest that L. paracasei SX52-B possesses distinct genomic features related to glucose-lowering pathways. On the other hand, the result of in vitro functional assay demonstrated that L. paracasei SX52-B exhibited a high α-amylase activity inhibition rate (94.67%) and favorable lipid-lowering capacity. The supernatant of L. paracasei SX52-B also exhibited significant antioxidant activity. To verify the hypoglycemic capacity of L. paracasei SX52-B in vivo, we employed a hyperglycemic zebrafish model. It is revealed that both supernatant and bacteria of L. paracasei SX52-B significantly reduced the glucose content in zebrafish (P < 0.001). The study findings highlight that L. paracasei SX52-B exhibits favorable probiotic properties and hypoglycemic capacity, holding promising potential for application in the development of functional hypoglycemic foods or pharmaceutical products.

Indexed as

Genomic analysisHypoglycemiaLacticaseibacillus paracaseiProbiotics

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PMID42862459

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