ArticleDiscover nano2026
Mapping biomedical hydrogel microspheres through scientometric and topic modeling analysis of emerging nano-enabled design strategies.
Article in Discover nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Hydrogel microspheres (HMs) are injectable microscale hydrogel platforms formed from crosslinked polymeric networks, with tunable porosity, stiffness, degradation behavior, surface chemistry, and cargo-loading capacity. Recent advances have expanded HMs beyond conventional controlled-release carriers into multifunctional biomedical platforms incorporating micro/nano-architectural designs, nanocomposite components, and biofunctional interfaces. However, the field-level evolution of biomedical HMs, including emerging nano-enabled design strategies, application landscapes, and validation requirements, remains insufficiently characterized. Here, we analyzed 4,399 English-language publications on biomedical HMs from the Web of Science Core Collection and PubMed between 2000 and 2025. Bibliometric mapping, co-citation analysis, keyword evolution analysis, disease/application-landscape mapping, and latent Dirichlet allocation topic modeling were integrated to identify publication growth, collaboration structures, intellectual bases, latent topics, and emerging material trends. The results show that controlled release and drug delivery remain foundational themes, whereas recent attention has increasingly focused on engineered HM platforms incorporating micro/nano-architectural features for wound healing, tissue engineering/cell delivery, bone regeneration, osteoarthritis/cartilage repair, and intervertebral disc degeneration. This study provides a data-driven map linking HM fabrication strategies, emerging micro/nano-architectural design approaches, material properties, biomedical functions, and translational validation requirements.Clinical Trial Number: Not applicable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.