Evidence map›Paper›PMID 42862352›Full record

ArticleArchives of microbiology2026

eIF3i inhibits nelson bay orthoreovirus replication via interaction with the σNS protein.

Pei-Jia Lu, Kun-Fang Li, Zhi-Wei Guo, Bo-Yu Chen, Yong-Gang Li, Xiao-Li Tao, Lv-Yin Sun

Abstract read
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In one paragraph

Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pei-Jia Lu *Department of Pathogenic Microbiology, College of Basic Medical Sciences, Jinzhou Medical University, No. 40, the Third Section of SongPo Rd, Jinzhou City, 121200, Liaoning Province, China.
Kun-Fang Li *Department of Pathogenic Microbiology, College of Basic Medical Sciences, Jinzhou Medical University, No. 40, the Third Section of SongPo Rd, Jinzhou City, 121200, Liaoning Province, China.
Zhi-Wei GuoDepartment of Pathogenic Microbiology, College of Basic Medical Sciences, Jinzhou Medical University, No. 40, the Third Section of SongPo Rd, Jinzhou City, 121200, Liaoning Province, China.
Bo-Yu ChenDepartment of Pathogenic Microbiology, College of Basic Medical Sciences, Jinzhou Medical University, No. 40, the Third Section of SongPo Rd, Jinzhou City, 121200, Liaoning Province, China.
Yong-Gang LiDepartment of Pathogenic Microbiology, School of Basic Medical Sciences, Shenyang Medical College, No. 146, Huanghe North Street, Huanggu District, Shenyang, 110034, Liaoning Province, China.
Xiao-Li TaoDepartment of Pathogenic Microbiology, College of Basic Medical Sciences, Jinzhou Medical University, No. 40, the Third Section of SongPo Rd, Jinzhou City, 121200, Liaoning Province, China.
Lv-Yin SunDepartment of Pathogenic Microbiology, College of Basic Medical Sciences, Jinzhou Medical University, No. 40, the Third Section of SongPo Rd, Jinzhou City, 121200, Liaoning Province, China. 15141994538@163.com.ORCID https://orcid.org/0009-0003-1048-5451

Funding

Liaoning Provincial Department of Science and Technology 2025-MSLH-249Undergraduate Innovation and Entrepreneurship Training Program of Jinzhou Medical University X202510160102
6 · The paper itself

Abstract

L929 cells exhibit relatively strong resistance to infection by Nelson Bay orthoreovirus (NBV), primarily due to the unique virus-host interaction that suppresses NBV infection at multiple stages, including viral entry, genome replication, and virion assembly. This study investigates the role of host factor eIF3i in NBV replication. Co-immunoprecipitation and immunofluorescence co-localization assays were performed to verify whether eIF3i interacts with the σNS protein in vitro. The results demonstrated that eIF3i significantly inhibits NBV replication through specific binding to σNS. This finding not only provides mechanistic insights into host protein-mediated regulation of viral replication, but also offers a theoretical basis for developing novel anti-NBV therapeutic strategies.

Indexed as

Eukaryotic Initiation Factor-3OrthoreovirusViral Nonstructural ProteinsVirus ReplicationAnimalsCell LineHost-Pathogen InteractionsMiceProtein BindingEukaryotic Initiation Factor-3Viral Nonstructural ProteinsEukaryotic initiation factor 3 subunit INelson Bay orthoreovirusProtein–protein interactionsSigma non-structural protein

Identifiers

PMID42862352

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.