ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2026
Effect of Dermal Fibroblast-Conditioned Media on Human Dermal Fibroblasts Treated With Electromagnetic Transduction Therapy.
Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElectromagnetic transduction therapy (EMTT) is a high-intensity pulsed electromagnetic field therapy used in musculoskeletal medicine. However, its therapeutic effects on human dermal fibroblasts (HDFs) remain unclear. Secretomes from human dermal fibroblast-conditioned medium (HDFCM) can enhance wound repair and tissue regeneration.
methodsYoung and aged HDFs were treated with EMTT (40 or 80 mT) following HDFCM pretreatment (0, 30, or 60%). Proliferation and migration were assessed using cell proliferation and wound healing assays. Senescence-associated β-galactosidase (SA-β-Gal) staining and enzyme-linked immunosorbent assay (ELISA) were performed to evaluate the effects of EMTT and HDFCM on senescence and pro- and anti-inflammatory cytokine secretion.
resultsHDFCM significantly enhanced the proliferation of young and aged HDFs, particularly aged cells, in a dose-dependent manner. EMTT at 40 mT further enhanced these effects, with 40 mT EMTT plus 30% HDFCM yielding the greatest increase in the number of aged HDF. SA-β-Gal activity, minimal in young cells, was elevated in aged HDFs, but was reduced by 40 mT EMTT with or without HDFCM. Contrastingly, 80 mT EMTT increased SA-β-Gal activity unless counteracted by 60% HDFCM. Moreover, interleukin-6 was upregulated and transforming growth factor-β was downregulated by HDFCM and EMTT treatments.
conclusionEMTT at low magnetic field strength, particularly if combined with HDFCM, promotes proliferation and migration while reducing senescence in aged HDFs. This approach may offer a promising therapeutic strategy for skin regeneration and antiaging applications, especially for aging or damaged dermal tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.