ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026
Matrix Metalloproteinase-8 Deficiency Alters the Balance Between Viral Clearance and Immunopathology in H1N1 Infection.
Xiaoyun Wang, Joselyn Rojas-Quintero, Duo Zhang, Joaquin Zuñiga, Caroline A Owen
Abstract read
In one paragraphArticle in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
5 authors.
Xiaoyun WangPulmonary Division, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Joselyn Rojas-QuinteroPulmonary Division, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Joaquin ZuñigaDepartment of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Caroline A OwenDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
Funding
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1MInstitutional Career Development CoreKL2TR002381 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Anandi Nayan Sheth · 2017 to 2026
$14.1MTargeting MMP9 to Improve Outcomes in Serious Influenza InfectionsR01AI111475 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HARROD, KEVIN S, LEVY, BRUCE D · 2014 to 2018
$4.3MNovel Roles for MMP-8 in Acute Lung InjuryR01HL063137 · NHLBI · UNIVERSITY OF UTAH · PI OWEN, CAROLINE A · 1999 to 2008
$2.6MNovel Roles for ADAM15 in Acute Lung InjuryR01HL086814 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI OWEN, CAROLINE A · 2007 to 2010
$1.6MNovel Anti-inflammatory Activities For ADAM8 In Pulmonary EmphysemaR21HL111835 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI OWEN, CAROLINE A · 2012 to 2013
$456kMMP-8 Deficiency Improves Host Responses to Influenza Viral InfectionsF32HL147437 · NHLBI · UNIVERSITY OF GEORGIA · PI WANG, XIAOYUN · 2019 to 2021
$205kMechanistic Insights of TIMP-1 in Influenza Virus InfectionR03AI169063 · NIAID · UNIVERSITY OF GEORGIA · PI WANG, XIAOYUN · 2022 to 2023
$151kDOW | MHS | Congressionally Directed Medical Research Programs (CDMRP) PR152060Flight Attendant Medical Research Institute (FAMRI) CIA123046HHS | NIH | National Center for Advancing Translational Sciences (NCATS) KL2TR002381HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR002378HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F32HL147437HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL063137HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL086814HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL111835HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI111475-01HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI169063NCATS NIH HHS KL2 TR002381NCATS NIH HHS UL1 TR002378NHLBI NIH HHS F32 HL147437NHLBI NIH HHS R01 HL063137NHLBI NIH HHS R01 HL086814NHLBI NIH HHS R21 HL111835NIAID NIH HHS R01 AI111475NIAID NIH HHS R03 AI169063
6 · The paper itselfAbstract
Matrix metalloproteinase-8 (MMP-8) regulates inflammatory responses, but its contributions to the pathogenesis of influenza A viral (IAV) disease are not known. Plasma MMP-8 levels were increased 30-fold in subjects infected with H1N1 or seasonal IAV and were inversely associated with the PaO
Indexed as
Influenza A Virus, H1N1 SubtypeInfluenza, HumanMatrix Metalloproteinase 8Orthomyxoviridae InfectionsAnimalsFemaleHumansLungMaleMiceMice, Inbred C57BLMice, KnockoutMatrix Metalloproteinase 8MMP8 protein, mouseadaptive immunityinnate immunitymurine models of influenza viral infectionnecroptosisType I interferons
Identifiers
PMID42861596
PMCPMC13656188
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