ArticleChemical communications (Cambridge, England)2026
Extended local deuteration of leucine enhances methyl NMR of large proteins expressed in eukaryotic cells.
Article in Chemical communications (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Many proteins of structural and mechanistic interest cannot be faithfully produced in bacteria and require eukaryotic expression systems. Yet NMR remains challenging as deuteration is difficult to achieve. Here, we present a strategy that extends our local deuteration of leucine sidechains to the β-position, further enhancing linewidth and signal intensity.
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