ArticleGenes, brain, and behavior2026
Effects of Serotonin Transporter Genotype and (Un)Predictable Maternal Separation on Affective, Cognitive, and Social Behaviors in Female Rats.
Article in Genes, brain, and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Serotonin transporter (SERT) variation is linked to depression risk after stress, conferring an increased risk to SERT-linked polymorphic region (5-HTTLPR) short-allele carriers, who show heightened sensitivity to cumulative stress and childhood maltreatment. To elucidate the neurobiological mechanisms underlying SERT × early-life adversity interactions, animal models capturing this genetic vulnerability are of translational relevance. We evaluated four maternal separation (MS) paradigms to determine how different forms of early-life stress influence adult behavior in female SERT-deficient rats, given the higher prevalence of depression in women and the limited translational value of male-only preclinical findings. We applied several behavioral tests to wildtype (SERT
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