Evidence map›Paper›PMID 42861377›Full record

ArticleMaterials today. Bio2026

An engineered exosome-based platform for targeted delivery to endogenous neural stem cells and fate modulation after spinal cord injury.

Qing Liu, Ang Lv, Yabin Lin, Jiawei Chen, Chunlei Zhang, Shuai Zhou, Liming Li, Luping Zhang, Weikang Wang, Fei Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qing LiuDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, China.
Ang LvShandong Key Lab of Complex Medical Intelligence and Aging, Shandong Medical and Pharmaceutical University, No. 318, Gangcheng East Street, Laishan District, Yantai, Shandong, 264003, China.
Yabin LinDepartment of Anatomy, School of Basic Medical Sciences, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou, Guangdong, 510515, China.
Jiawei ChenShandong Key Lab of Complex Medical Intelligence and Aging, Shandong Medical and Pharmaceutical University, No. 318, Gangcheng East Street, Laishan District, Yantai, Shandong, 264003, China.
Chunlei ZhangShandong Key Lab of Complex Medical Intelligence and Aging, Shandong Medical and Pharmaceutical University, No. 318, Gangcheng East Street, Laishan District, Yantai, Shandong, 264003, China.
Shuai ZhouShandong Key Lab of Complex Medical Intelligence and Aging, Shandong Medical and Pharmaceutical University, No. 318, Gangcheng East Street, Laishan District, Yantai, Shandong, 264003, China.
Liming LiSchool of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, No. 369 Dengyun Road, Qingdao, 266071, China.
Luping ZhangShandong Key Lab of Complex Medical Intelligence and Aging, Shandong Medical and Pharmaceutical University, No. 318, Gangcheng East Street, Laishan District, Yantai, Shandong, 264003, China.
Weikang WangInstitute of Rehabilitation Medicine, School of Special Education and Rehabilitation, Shandong Medical and Pharmaceutical University, No. 318, Gangcheng East Street, Laishan District, Yantai, Shandong, 264003, China.
Fei HuangDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) disrupts neural circuits, leading to persistent sensory and motor deficits. However, effective strategies to promote repair through endogenous neural stem cells (eNSCs) are still limited. In this work, we engineered exosomes with a newly identified peptide (TGP1) to achieve targeted delivery to eNSCs. These exosomes were further loaded with Apelin to stimulate eNSC activation and neuronal differentiation. Following tail-vein administration, TGP1-modified exosomes showed greater accumulation in the injured spinal cord and a 4.6-fold increase in co-localization with Nestin

Indexed as

ApelinDifferentiationEndogenous neural stem cellExosomePhage display-derived peptidesSpinal cord injury

Identifiers

PMID42861377
PMCPMC13654498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.