ArticleQuantitative imaging in medicine and surgery2026
Combined non-contrast enhancement 3D bright-blood and 2D black-blood coronary magnetic resonance angiography for the assessment of coronary artery stenosis.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Non-contrast coronary magnetic resonance angiography (CMRA) offers a radiation- and contrast-free alternative for evaluating coronary artery disease, yet its clinical adoption has been constrained by suboptimal specificity, primarily due to flow-related artifacts and signal loss inherent to bright-blood imaging. Black-blood vessel wall imaging, by suppressing intraluminal blood signal, enables direct visualization of the coronary wall and may complement bright-blood CMRA to improve diagnostic accuracy. However, the additive value of a targeted sequential protocol combining these two techniques remains to be established. The objective of this study was to evaluate whether a sequential protocol combining three-dimensional (3D) bright-blood CMRA with lesion-directed two-dimensional (2D) black-blood coronary magnetic resonance (CMR) improves the diagnostic performance of non-contrast CMRA for detecting coronary artery stenosis, using computed tomography angiography as the reference standard. Methods: From January 2025 to April 2025, consecutive patients with suspected coronary artery disease who were scheduled for dual-source computed tomography angiography and consented to undergo 3.0-T non-contrast CMRA were enrolled. The imaging protocol comprised free-breathing 3D bright-blood whole-heart CMRA, followed by lesion-directed 2D black-blood CMRA performed exclusively in segments with equivocal or suspicious findings on bright-blood imaging. Coronary computed tomography angiography (CCTA) served as the primary reference standard, with ICA performed in a subset of nine patients. Diagnostic performance for detecting significant (>50% diameter stenosis) and mild (25-49%) stenosis was assessed on a per-segment basis. Comparative analyses between bright-blood CMRA alone and the combined approach were performed using the McNemar test for paired proportions and DeLong's method for receiver operating characteristic (ROC) curves. Results: A total of 114 vessel segments from 104 patients (mean age 63±13 years; 63 men)were included in the final analysis. The combination of bright-blood CMRA and 2D black-blood CMR demonstrated superior diagnostic performance compared with bright-blood CMRA alone for identifying significant stenosis (>50% diameter stenosis). Sensitivity was 97.9% [95% confidence interval (CI), 88.9-99.9%] versus 87.5% (95% CI, 72.3-93.9%; P=0.031), specificity was 98.5% (95% CI, 91.8-100.0%) versus 68.1% (95% CI, 52.4-76.5%; P<0.001), accuracy was 98.2% (95% CI, 93.8-99.8%) versus 76.3% (95% CI, 64.6-81.5%; P<0.001), and the area under the receiver operating characteristic curve (AUC) was 0.98 (95% CI, 95.2-99.1%) versus 0.75 (95% CI, 66.2-82.1%; P<0.001). In addition, the combined approach correctly identified non-significant stenosis (25-49% diameter stenosis) in 32 of 35 segments and significantly improved sensitivity [91.4% (95% CI, 76.8-98.0%) Conclusions: The combination of 3D bright-blood CMRA and 2D black-blood CMR significantly enhances the diagnostic performance of non-contrast CMRA for detecting both significant and mild coronary artery stenosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.