ArticleQuantitative imaging in medicine and surgery2026
Determining malignancy in thyroid nodules featuring anterior macrocalcifications with strong posterior acoustic shadowing: the combined utility of US-FNA and
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Thyroid nodules with anterior macrocalcifications and strong posterior acoustic shadowing present diagnostic challenges due to uncertain malignancy risk. The diagnostic value of combining ultrasound-guided fine needle aspiration (US-FNA) with Methods: A retrospective study of 79 thyroid nodules exhibiting macrocalcifications at the anterior margin with strong posterior acoustic shadowing was performed. Based on sonographic features, we classified hyperechoic macrocalcifications into four subtypes: Type I (smooth arc-shaped eggshell-like), Type II (discontinuous arc-shaped, irregularly thickened), Type III (multiple macrocalcifications arranged as layers), and Type IV (multiple macrocalcifications stacked or clustered together). According to Results: The proportion of Type II macrocalcification was relatively high (70.0%) in the Conclusions: Thyroid nodules featuring anterior macrocalcifications with strong posterior acoustic shadowing carry a significant moderate risk, and Type II calcification serves as a key imaging biomarker for malignancy. Combining US-FNA with
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