Evidence map›Paper›PMID 42861157›Full record

ArticleBurns & trauma2026

A neutrophil-epithelial thrombospondin‑1-CD36-c‑Jun N‑terminal kinase axis orchestrates mucosal barrier failure in intestinal ischemia-reperfusion.

Yiwen Wang, Ran Li, Mengmeng Zhuang, Yuechen Fu, Qing Xu, Luqi Qiao, Simiao Chen, Jiayi Cao, Kehui Li, Ao Wang and 3 more

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Article in Burns & trauma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Yiwen WangDepartment of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.
Ran LiDepartment of Burn Surgery, The 71st Group Army Hospital of People's Liberation Army, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.
Mengmeng ZhuangDepartment of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.
Yuechen FuDepartment of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.
Qing XuDepartment of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.
Luqi QiaoDepartment of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.
Simiao ChenDepartment of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.
Jiayi CaoDepartment of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.
Kehui LiDepartment of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.
Ao WangDepartment of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.
Chao MengDepartment of Burn Surgery, The 71st Group Army Hospital of People's Liberation Army, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.
Wensheng WangDepartment of Burn Surgery, The 71st Group Army Hospital of People's Liberation Army, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.
Yong SunDepartment of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University, 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004, China.ORCID https://orcid.org/0000-0001-5720-2779

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Intestinal barrier failure following ischemia-reperfusion (IR) injury is a critical event that drives lethal systemic complications; however, the specific intercellular signals governing epithelial cell fate under these pathological conditions remain incompletely understood. Methods: We performed single-cell ribonucleic acid sequencing (scRNA-seq) on intestinal tissues from a murine IR model to map intercellular communication networks. The identified ligand-receptor pair was functionally validated using neutrophil-specific thrombospondin-1 ( Results: scRNA-seq analysis of the IR-injured gut revealed a key neutrophil-epithelial signaling pathway mediated by the Conclusions: Our study elucidates a key mechanism of gut barrier failure and identifies the THBS1-CD36-JNK axis as a promising therapeutic target for mitigating intestinal IR injury in critical conditions such as burns and shock.

Indexed as

ApoptosisCD36Intestinal ischemia–reperfusion injuryIntestinal mucosal barrierJNK signalingNeutrophilsThrombospondin-1

Identifiers

PMID42861157
PMCPMC13654182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.