ArticleInternational journal of women's health2026
Reference Intervals of Hematological Parameters Among Healthy Pregnant Women in Eastern Sudan: A Prospective Longitudinal Cohort Study.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pregnancy induces maternal hematological adaptations. Because these shifts are influenced by environmental, nutritional, and ethno-geographic variations, relying on international adult reference intervals (RIs) may increase the risk of diagnostic misclassification. Given the scarcity of context-specific reference intervals in Sudan, this study aimed to establish the localized, trimester-specific complete blood count (CBC) RIs for healthy pregnant women in Eastern Sudan. Methods: This hospital-based longitudinal cohort study included apparently healthy pregnant women during their first trimester and followed up till the third trimester at Gadarif Maternity Hospital. CBC parameters were analyzed using a Sysmex KX-21 automated analyzer. Following CLSI guidelines, trimester-specific 95% RIs were determined non-parametrically by calculating the central 2.5 Results: Of the 120 included, total white blood cell (WBC) counts increased significantly from the first trimester median of 7.6 ×10 Conclusion: This study showed that CBC parameters vary significantly across trimesters and differ from international baselines. The second-trimester hemoglobin lower boundary of 9.1g/dL and late-pregnancy gestational thrombocytopenia need further validation in larger and more diverse populations before routine clinical use.
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