ArticleQuantitative imaging in medicine and surgery2026
Evaluation of a personalized total iodine dose (TID) combined with fixed injection duration (FID) protocol using high-concentration (400 mgI/mL) iodinated contrast medium in CT portal venography: a randomized trial.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The portal vasculature is closely associated with clinical outcomes in liver disease. Contrast-enhanced computed tomography (CT) serves as the first-line noninvasive tool for its evaluation. The contrast administration strategy critically influences CT image quality and diagnostic performance. This study aimed to investigate the effect of a personalized total iodine dose (TID) combined with a fixed injection duration (FID) protocol on CT imaging of the portal vein using a high-concentration iodine contrast medium (CM). Methods: A GE 64-slice spiral CT scanner and a 400 mgI/mL iodine CM were used. The total CM dose was calculated based on the patient's total body weight (TBW) at doses of either 400 or 450 mgI/kg. The FID was set at 18 or 20 s, and the tube voltage was set at 100 or 120 kVp. These three parameters were varied to generate eight distinct injection and scanning protocols. Eligible patients were randomized into eight groups. The CT values of the main portal vein (CT Results: Lower tube voltage significantly increased CT Conclusions: When using high-concentration iodine CM, all imaging protocols achieved satisfactory portal vein enhancement. The protocol combining a lower flow rate (20-s FID), a lower TID (400 mgI/kg), and a tube voltage of 100 kVp improved portal vein CT values and reduced radiation dose without compromising image quality, and thus represents a promising protocol for clinical CT portal venography.
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