ArticleCureus2026
Safety and Recovery Profile of Propofol-Based Intravenous Sedation for Endoscopic Retrograde Cholangiopancreatography in Adults: A Prospective Single-Center Observational Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic retrograde cholangiopancreatography (ERCP) frequently requires deep sedation, but prone positioning, restricted airway access, and variable procedural duration create important safety concerns. We evaluated respiratory and hemodynamic events, recovery, and satisfaction during propofol-based intravenous sedation.
methodsThis prospective, single-center observational study included 100 adults with American Society of Anesthesiologists physical status I or II who underwent elective ERCP for common bile duct stones at King Khalid Hospital in Saudi Arabia from June 2025 to June 2026. Patients received midazolam 2 mg and fentanyl 1 µg/kg intravenously, followed by a propofol infusion of 30-50 µg/kg/minute and 20-30 mg boluses as needed. Patients were prone and received oxygen at 3 L/min through a nasal cannula with an incorporated carbon dioxide sampling line. Standard variables were recorded every five minutes, with continuous waveform capnography. Exact binomial 95% confidence intervals (CIs) were calculated for adverse-event proportions, and Spearman correlation assessed associations with propofol bolus count.
resultsThe mean age was 35.1 ± 7.2 years, 53 (53%) were female patients, and 73 (73%) had physical status I. The mean procedure duration was 65.3 ± 12.7 minutes. No oxygen desaturation or tracheal intubation occurred (0/100 (0%); 95% CI, 0-3.6 for each). Airway maneuvers and procedural interruption occurred in the same five patients (5/100 (5%); 95% CI, 1.6-11.3), and postoperative nausea and vomiting (PONV) occurred in four patients (4/100 (4%); 95% CI, 1.1-9.9). Median recovery time was five minutes (interquartile range (IQR), 5-6), and median recovery-room stay was 20 minutes (IQR, 20-20). Mean patient and endoscopist satisfaction scores were 9.63 ± 0.71 and 9.65 ± 0.77, respectively. Longer procedures were associated with more propofol boluses (Spearman ρ = 0.448; p < 0.001), whereas bolus count was not associated with recovery time (ρ = 0.123; p = 0.225).
conclusionIn this selected, low-risk cohort, propofol-based intravenous sedation with nasal waveform capnography was associated with no recorded hypoxemia or intubation, infrequent airway intervention and PONV, rapid recovery, and high satisfaction. Larger comparative studies using standardized respiratory definitions and prospectively defined capnographic outcomes are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.