ReviewRegenerative therapy2026
Multifunctional hydrogel scaffolds for endogenous osteochondral regeneration.
Review in Regenerative therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Osteochondral defects, frequently resulting from trauma, infection, or degenerative joint disease, present a significant clinical challenge due to their limited intrinsic healing capacity. Conventional cell-based therapies face limitations including immune rejection, high costs, and regulatory hurdles. Endogenous tissue engineering, which harnesses the body's own repair machinery through biomaterial-mediated recruitment and differentiation of host stem cells, offers a promising alternative. Hydrogel scaffolds, owing to their extracellular matrix-mimetic architecture, tunable physicochemical properties, and capacity for bioactive factor delivery, have emerged as versatile platforms for endogenous osteochondral regeneration. This review provides a strategic overview of hydrogel-based endogenous tissue engineering, covering: (1) the biological rationale for leveraging host cell sources; (2) the design of hydrogels as extracellular matrix -mimetic niches; (3) key regulatory factors; (4) innovative material design strategies. We also discuss current challenges related to long-term functionality, scaffold integration, and clinical translation, offering insights into the development of next-generation hydrogel systems for minimally invasive and effective osteochondral regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.