Evidence map›Paper›PMID 42861038›Full record

ArticleBlood vessels, thrombosis & hemostasis2026

Interindividual variability in platelet aggregation among aspirin-treated patients: a large retrospective analysis.

Eleonora Schiera, Simone De Corci, Sergio Terracina, Gioacchino Galardo, Gianluca Di Pietro, Massimo Mancone, Fabio M Pulcinelli

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Article in Blood vessels, thrombosis & hemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Eleonora SchieraDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Simone De CorciDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Sergio TerracinaDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Gioacchino GalardoDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Gianluca Di PietroDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Massimo ManconeDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Fabio M PulcinelliDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interindividual variability in response to aspirin remains a major challenge in antiplatelet therapy. Identification of patients with high platelet reactivity (HPR) and optimal or low platelet reactivity remains challenging and may be influenced by both biological and methodological factors, including interlaboratory variability. We report results of a large cohort of aspirin-treated patients to assess the gold standard light transmission aggregometry (LTA). We retrospectively analyzed 3065 patients treated with aspirin (ASA; 75-150 mg/d) who sequentially underwent LTA assessment using multiple agonists (adenosine diphosphate [ADP] 2μM, collagen 2 μg/mL, arachidonic acid [AA] 0.75mM, and epinephrine 10μM). Patients were stratified according to AA-induced platelet aggregation using a 16% cutoff (third quartile). Patients with AA >16% showed significantly higher platelet aggregation across all agonists (

Identifiers

PMID42861038
PMCPMC13653970

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