ReviewThe Japanese dental science review2026
Root canal microbiota in diabetic versus non-diabetic patients with apical periodontitis: A systematic review.
Review in The Japanese dental science review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Background: This systematic review aimed to evaluate the differences in root canal microbiota composition and microbial load between diabetic and non-diabetic individuals with apical periodontitis. Methods: Electronic searches were conducted in PubMed/MEDLINE, Scopus, Web of Science, Google Scholar, the Cochrane Library and EBSCO up to 9 April 2026.Clinical studies using culture-dependent or molecular methods to identify microbial taxa in infected root canals of diabetic and non-diabetic individuals were included. Data on diabetes status, infection type, microbiological method, identified taxa, and quantitative microbial outcomes were extracted. Methodological quality was assessed using the Joanna Briggs Institute critical appraisal tool. Results: Sixteen studies were included. Most used molecular methods, while few used culture or combined culture/molecular approaches. The studies varied in infection type, microbiological method, glycemic status reporting, and outcome metrics. Several studies reported differences in the prevalence or relative abundance of selected bacterial taxa in diabetic patients, including Conclusion: Diabetes mellitus may be associated with differences in the reported endodontic microbial profile of teeth with apical periodontitis. However, the evidence is observational, clinically heterogeneous, and limited by small sample sizes, inconsistent glycemic reporting, and inadequate control of confounding factors.
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