ReviewRegenerative therapy2026
Adipose-derived microvascular fragments: Functional microtissue units driving vascular integration and multidimensional tissue regeneration.
Review in Regenerative therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid and stable vascularization remains one of the major challenges in regenerative medicine and tissue engineering. Adipose-derived microvascular fragments (ad-MVFs) have emerged as a promising vascularization strategy because they preserve intact microvascular architecture while retaining endothelial cells, perivascular cells, extracellular matrix, and niche components. Unlike conventional strategies that primarily rely on host-driven angiogenesis, ad-MVFs can rapidly integrate with the host vasculature and establish functional perfusion. Beyond vascularization, ad-MVFs contribute to tissue remodeling, immune regulation, and microenvironment restoration. These properties have enabled their applications in ischemic tissue repair, soft tissue regeneration, metabolic tissue engineering, disease modeling, and biofabrication. This review summarizes current knowledge of ad-MVF biology, isolation and preservation strategies, mechanisms of vascular integration, and emerging biomedical applications. We also discuss key challenges for clinical translation and future development opportunities. By viewing ad-MVFs as functional microtissue units, this review highlights their potential as a versatile platform for regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.