ArticlePhysical activity and nutrition2026
Effects of a low-protein, high-fructose corn syrup diet on skeletal muscle and bone in young adult mice: a pilot study.
Article in Physical activity and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to examine the effects of chronic consumption of a low-protein diet combined with 10% high-fructose corn syrup (HFCS) on skeletal muscle and bone health in mice.
methodsSeven-week-old male C57BL/6 mice were fed either a normal diet or a low-protein diet supplemented with 10% HFCS for 12 weeks. Gene expression in skeletal muscle was analyzed by real-time PCR, and bone microarchitecture was evaluated using micro-CT.
resultsMice fed the low-protein diet supplemented with HFCS exhibited reduced body weight and lower gastrocnemius, heart, and femur weights. In the gastrocnemius muscle, genes related to muscle growth, glucose transport, and mitochondrial regulation were significantly downregulated, whereas no significant changes were observed in the soleus muscle. Additionally, trabecular bone volume fraction and number were significantly reduced, whereas cortical bone thickness remained unchanged.
conclusionChronic intake of a low-protein diet supplemented with HFCS was associated with altered skeletal muscle metabolic gene expression, with potential differences between muscle types and changes in trabecular bone microarchitecture, suggesting potential adverse effects of combined nutritional stress on musculoskeletal health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.