Evidence map›Paper›PMID 42860698›Full record

ArticleGlia2026

Myelin Maintenance and Addition Regulate Synaptic Plasticity in the Adult Mouse Cortex.

Renee E Pepper, Kalina Makowiecki, Kimberley A Pitman, Raphael Ricci, Angela L Nicoli, Phuong Tram Nguyen, Catherine A Blizzard, Ben Emery, Carlie L Cullen, Kaylene M Young

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Renee E PepperMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Kalina MakowieckiMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Kimberley A PitmanMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Raphael RicciMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.ORCID https://orcid.org/0000-0001-8722-8021
Angela L NicoliMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.ORCID https://orcid.org/0009-0001-5138-9218
Phuong Tram NguyenMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Catherine A BlizzardMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Ben EmeryOregon Health and Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-9132-3045
Carlie L CullenMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.ORCID https://orcid.org/0000-0001-6929-6258
Kaylene M YoungMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.ORCID https://orcid.org/0000-0002-1686-3463

Funding

Australian Research Council DP180101494Australian Research Council DP220100100Equity TrusteesMater FoundationMedical Research Future Fund EPCD08Menzies Institute for Medical ResearchMultiple Sclerosis Australia 11-014Multiple Sclerosis Australia 15-054Multiple Sclerosis Australia 16-105Multiple Sclerosis Australia 17-0223Multiple Sclerosis Australia 19-0696Multiple Sclerosis Australia 20-460Multiple Sclerosis Australia 21-4-017National Health and Medical Research Council 1030939National Health and Medical Research Council 1045240National Health and Medical Research Council 1077792National Health and Medical Research Council 2012140Trusts of L G McCallum Est
6 · The paper itself

Abstract

Myelin has the capacity to affect synapse number or plasticity across the lifespan. We report that disrupting oligodendrocyte (OL) and myelin maintenance from P57 (Plp-CreER

Indexed as

Motor CortexMyelin SheathNeuronal PlasticityAction PotentialsAnimalsDendritic SpinesExcitatory Postsynaptic PotentialsMiceMice, Inbred C57BLMice, TransgenicOligodendrogliaPyramidal CellsdemyelinationdendriteexcitationglutamatemEPSCmyelinmyelin regulatory factor (Myrf)oligodendrocyteplasticityspine

Identifiers

PMID42860698
PMCPMC13655357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.