ArticleChemical biology & drug design2026
Kcnn4 Knockout Induces Salivary Gland Fibrosis, Immune Cell Infiltration, and B-Cell Dysfunction in Mice.
Yuan Zhang, Siming Zheng, Degui Jiang, Cuiyun Cui, Xuan Zhang, Hanlin Tao, Gongbo Fu, Linna Cheng, Shichao Duan
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In one paragraphArticle in Chemical biology & drug design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Yuan ZhangDepartment of Clinical Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, and People's Hospital of Henan University, Zhengzhou, China.ORCID https://orcid.org/0000-0002-9297-8932 Cuiyun CuiDepartment of Transfusion Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, and People's Hospital of Henan University, Zhengzhou, China.ORCID https://orcid.org/0009-0004-2160-3043 Xuan ZhangHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China.ORCID https://orcid.org/0009-0008-1570-7929 Hanlin TaoHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China.ORCID https://orcid.org/0009-0001-7169-7226 Linna ChengInstitute of Hematology, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, Henan, China.ORCID https://orcid.org/0009-0006-4508-5329 Shichao DuanHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China.ORCID https://orcid.org/0000-0002-3177-4194 Funding
Henan Medical Science and Technology Research Project LHGJ20250094Henan Science and Technology Research Project 252102310141
6 · The paper itselfAbstract
Kcnn4 (KCa3.1) is a calcium-activated potassium channel involved in cell volume regulation and immune cell function, but its role in salivary gland homeostasis remains poorly understood. In this study, we generated constitutive Kcnn4 knockout (Kcnn4
Indexed as
B-LymphocytesIntermediate-Conductance Calcium-Activated Potassium ChannelsSalivary GlandsAnimalsFibrosisMiceMice, Inbred C57BLMice, KnockoutIntermediate-Conductance Calcium-Activated Potassium ChannelsKcnn4 protein, mousefibrosisIgG deficiencyinflammatory proteomicsKcnn4 (KCa3.1)lymphocyte infiltrationsalivary gland
Identifiers
PMID42860661
PMCPMC13655356
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