Evidence map›Paper›PMID 42860620›Full record

ArticleBasic & clinical pharmacology & toxicology2026

Mechanisms of XCR1 Membrane Trafficking and Constitutive Endocytosis.

Qiao Li, Fabian Pfersdorf, Fernando Salgado-Polo, Martin Gustavsson

Abstract read
In one paragraph

Article in Basic & clinical pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qiao LiDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0009-0001-8719-0526
Fabian PfersdorfDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0009-0002-2485-330X
Fernando Salgado-PoloDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-8362-5281
Martin GustavssonDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-3015-2043

Funding

Carlsbergfondet CF19-0320Danmarks Frie Forskningsfond 3103-00230BKræftens Bekæmpelse R389-A22939Villum Fonden 00025326
6 · The paper itself

Abstract

Chemokines orchestrate immune cell trafficking through receptor-mediated signalling and are implicated in inflammatory, autoimmune and neuropathic disorders. The XCL1-XCR1 axis is of particular interest because XCR1 is selectively expressed on mature conventional type 1 dendritic cells (cDC1s), where it supports communication with activated CD8

Indexed as

Cell MembraneDendritic CellsEndocytosisOrexin ReceptorsAnimalsbeta-ArrestinsChemokines, CHEK293 CellsHumansProtein TransportReceptors, G-Protein-CoupledSignal Transductionbeta-ArrestinsChemokines, COrexin ReceptorsReceptors, G-Protein-CoupledXCR1 protein, humanchemokine receptorG protein–coupled receptorreceptor internalizationreceptor traffickingXCR1

Identifiers

PMID42860620
PMCPMC13655292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.