ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Drug Repurposing for Treating NCOR-Related Intellectual Disability.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C Ciliberto and 6 more
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
16 authors.
Yan Kong *Department of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Zihan HuangDepartment of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Zhiyue LiuDepartment of Pediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China.
Chenyan LiMyGenostics Inc., Beijing, China.
Yi LuDepartment of Medicine - Division of Endocrinology, Baylor College of Medicine, Houston, Texas, USA.
Chengchuang SongDepartment of Medicine - Division of Endocrinology, Baylor College of Medicine, Houston, Texas, USA.
Makenna MackDepartment of Medicine - Division of Endocrinology, Baylor College of Medicine, Houston, Texas, USA.
Fang LuoMyGenostics Inc., Beijing, China.
Aihua CaoDepartment of Pediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China.
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MTissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3MTranslational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Casey W Wright · 2019 to 2026
$14.7MTraining in Precision Environmental Health SciencesT32ES027801 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2018 to 2026
$2.8MInter- and transgenerational effects of paternal arsenic exposureR01ES034768 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Zheng Sun · 2023 to 2026
$1.9MCircadian clock gene Rev-erb in memory dysfunction in Alzheimer's diseaseRF1AG069966 · NIA · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2021 to 2021
$1.8MChemically inducible split base editors for precise and controllable in vivo genome editingR01HL173243 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Xue Gao, Zheng Sun · 2025 to 2026
$1.3MCircadian clock gene Rev-erb in memory dysfunction in Alzheimer's diseaseR01AG069966 · NIA · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2024 to 2025
$1.1MAmerican Diabetes Association ADA1-19-PDF-012Frank Belton Kimmel and Sandra Kimmel Endowed Post-Doctoral FellowshipGulf Coast Center for Precision Environmental Health GC-CPEHGulf Coast Center for Precision Environmental Health P30ES030285Gulf Coast Consortia (GCC) on the Training in Precision Environmental Health Sciences (TPEHS) Program T32ES027801Human Tissue Acquisition and Pathology Core at Baylor College of Medicine CA125123Intellectual and Developmental Disabilities Research Center P50103555National Institution on Aging AG069966National Natural Science Foundation of China 82371532NCI NIH HHS P30 CA125123Neurobehavioral Core at Baylor College of MedicineNHLBI NIH HHS HL173243NHLBI NIH HHS R01 HL173243NIA NIH HHS R01 AG069966NIA NIH HHS RF1 AG069966NIDDK NIH HHS P30 DK056338NIEHS NIH HHS ES034768NIEHS NIH HHS P30 ES030285NIEHS NIH HHS R01 ES034768NIEHS NIH HHS T32 ES027801Texas Medical Center Digestive Diseases Center P30DK056338
6 · The paper itselfAbstract
Nuclear receptor corepressors (NCOR1/2) mediate the transcriptional activity of methyl-CpG binding protein 2 (MECP2), and genetic variants in NCOR1/2 or MECP2 associate with autism or intellectual disability. However, it is unknown whether heterozygous NCOR mutations impair cognitive functions and how NCOR-related intellectual disability can be treated. Here, we constructed a knock-in (KI) mouse line carrying a heterozygous NCOR1 mutation (NCOR1 c.2182+2T>G) found in a pediatric patient. These NCOR1
Indexed as
allopregnanolonedownregulation and upregulationdrug repositioninghaploinsufficiencyintellectual disabilityknockout mousemecp2neuregulin 1neuroactive steroidspironolactone
Identifiers
PMID42860618
PMCPMC13655318
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