Evidence map›Paper›PMID 42860567›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Gonadotropin-Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress-Induced Activation of the Locus Coeruleus-SAM Axis.

Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang and 9 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jiani Zhang *College of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Hongyu Zhu *College of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Wenqi WangCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Bingqian ShenCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Yuanyuan XinCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Xingxing SongCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Xuanyi LuCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Lixuan LiCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Siting ChenCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Xiaochen ZhangCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Jialing ZengCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Haodong ZhengCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Jianlong LaoCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Ke PengCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Yixian WeiCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Jiaming ZhengCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Chuanhuo HuCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Xiaoye WangCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Xun LiCollege of Animal Science and Technology, Guangxi University, Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.ORCID https://orcid.org/0000-0002-4850-2064

Funding

Innovation Project of Guangxi Graduate Education YCSW2024126National Natural Science Foundation of China 32160818National Natural Science Foundation of China 32360864Natural Science Foundation of Guangxi Province 2021GXNSFAA196001
6 · The paper itself

Abstract

Gonadotropin-inhibitory hormone (GnIH, also known as RFamide-related peptide-3, RFRP-3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress-induced reproductive suppression, its role in broader stress responses remains unclear. This study investigated the fuction of GnIH in acute stress and evaluated the mechanisms by which GnIH regulates norepinephrine (NE) release and activates the locus coeruleus-sympathetic-adrenal medulla (LC-SAM) axis in mice. The results show that GnIH is co-localized and co-stored with NE in sympathetic nerve terminals and that it is associated with heightened LC-SAM axis activity induced by acute stressors. Central or peripheral administration of GnIH potentiated acute stress responses and activated the LC-SAM axis, accompanied by increased anxiety-like behaviors. Conversely, genetic ablation of GnIH or GPR147 attenuated acute stress-induced anxiety-like behaviors and LC-SAM axis activation. Mechanistically, both central and peripheral GnIH enhanced NE synthesis, transport and release. These findings indicate that GnIH mimics or augments endogenous NE signaling to activated the LC-SAM axis during acute stress. Pharmacological modulation of the GnIH/GPR147 system may represent a therapeutic approach for the inhibiting maladaptive stress responses and stress-related pathologies and infertility.

Indexed as

acute stressanxiety‐like behaviorgonadotropin‐inhibitory hormone (GnIH)LC‐SAM axissympathetic neurotransmitter

Identifiers

PMID42860567
PMCPMC13655255

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.