Trial reportBMC oral health2026
Effect of injectable platelet rich fibrin augmented with vitamin c compared to injectable platelet rich fibrin alone on healing of necrotic mature single rooted teeth with chronic periapical periodontitis following regenerative endodontic therapy (a randomized controlled trial).
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05585359 (Effect of Injectable Platelet Rich Fibrin Augmented With Vitamin C Compared to Injectable Platelet Rich Fibrin Alone on Healing of Necrotic Mature Single Rooted Teeth With Chronic Peri-apical Periodontitis Following Regenerative Endodontics), which is not on this map. Not yet cited in PubMed.
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Effect of Injectable Platelet Rich Fibrin Augmented With Vitamin C Compared to Injectable Platelet Rich Fibrin Alone on Healing of Necrotic Mature Single Rooted Teeth With Chronic Peri-apical Periodontitis Following Regenerative Endodontics (A Randomized Controlled Trial)
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4 authors.
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Abstract
objectivesTo assess the healing potential, postoperative pain and clinical normalcy associated with injectable platelet-rich fibrin combined with Vitamin C in regenerative endodontic procedure using cone-beam computed tomography and two-dimensional radiograph.
methodsTwenty-eight healthy patients with mature permanent single-rooted teeth diagnosed with pulp necrosis and chronic apical periodontitis were randomly allocated into two groups (n = 14). Regenerative endodontic treatment was performed using injectable platelet-rich fibrin combined with Vitamin C (intervention group) and injectable platelet-rich fibrin alone (control group). Periapical healing was assessed using CBCT and periapical radiographs over 12 months. Postoperative pain and clinical normalcy were also evaluated.
resultsBoth groups showed significant lesion reduction at 12 months (P = 0.001), with no significant between-group differences in postoperative lesion size (P = 0.981) or reduction magnitude (P = 0.497). CBCT-PAI scores improved in both groups without significant intergroup differences at baseline or follow-up. Two-dimensional radiographs showed a baseline difference (P = 0.007) but no postoperative differences; both groups demonstrated significant longitudinal reduction (P < 0.001). Postoperative pain scores were comparable between groups at all time points (P > 0.05), with a significant temporal decrease observed only in the intervention group (P = 0.001). All teeth remained asymptomatic during follow-up.
conclusionsBoth i-PRF combined with vitamin C and i-PRF alone appear to be effective regenerative scaffolds, demonstrating comparable clinical and radiographic outcomes in regenerative endodontic procedures. CLINICAL
trial registrationThe study was registered with ClinicalTrials.gov (ID: NCT05585359), registered on 14 October 2022. Available at https://clinicaltrials.gov/study/NCT05585359 .
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