ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2026
Neurotensin modulation of immune and oxido-inflammatory homeostasis targeting TGF-β activated kinase 1/Nuclear factor-kappa βeta pathway: an integrated in vivo and in silico study.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNeurotensin (NTS) is a brain peptide and is known to regulate several brain pathways. Subsequently NTS involvement in psychosis was administered having its promising therapeutic effects as an antipsychotic drug. Therefore, it has been deduced that targeting the NTS system in the regulation of the immune organs would prove to be a productive strategy for developing the novel immune modulatory drugs.
objectiveThe present study elucidated the potential anti-inflammatory properties of NTS receptor 1 (NTSR1) agonist PD149163 (PD) in modulation of immune organs specifically, spleen and thymus investigating the potential immunomodulatory mechanisms targeting NF-κB /TAK1 signaling pathway.
methodsSwiss albino female mice were randomly grouped: Group I-control, treatment groups- Group II, Group III and Group IV were intraperitoneally exposed with NTSR1-agonist PD low dose/ PD
resultsThe levels of Nuclear factor kappa beta/NF-κB, Tumor necrosis factor- alpha/TNF-α, Interleukine-6/IL-6, Corticosterone/CORT and pro-oxidant, Lipid-peroxidation/LPx were visibly similar to control after the treatment of PD
conclusionNTS receptor 1 analogs might provide a better understanding of the mechanisms by which NTS regulates immune-system and could be further exploited for managing various immune-related disorders.
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