Evidence map›Paper›PMID 42860432›Full record

ArticleDiabetologia2026

Genetic background modulates MafA

Zachary Loyd, Dongsoo Lee, Mallory Maurer, Lizabeth Johnson, Jin-Hua Liu, Garrett Reynolds, Mark P Keller, Jean-Philippe Cartailler, Mark A Magnuson, Roland Stein and 1 more

Abstract read
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In one paragraph

Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zachary LoydDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Dongsoo LeeDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Mallory MaurerDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Lizabeth JohnsonDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jin-Hua LiuDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Garrett ReynoldsDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Mark P KellerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Jean-Philippe CartaillerDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Mark A MagnusonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Roland SteinDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Jeeyeon ChaDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. jeeyeon.cha@vumc.org.

Funding

MULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9M
Genetic Control of Metabolic Flux in Response to DietRC2DK125961 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI ATTIE, ALAN D · 2020 to 2024
$8.1M
Defining the Role of MafA in Islet Beta CellsR01DK090570 · NIDDK · VANDERBILT UNIVERSITY · PI PARENT, AUDREY, STEIN, ROLAND W · 2011 to 2025
$5.9M
The Diversity Outbred Diabetes ProjectR01DK101573 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Alan D Attie · 2014 to 2026
$5.3M
The Role of Sorcs1 and Sortilin in Diabetes SusceptibilityR01DK102948 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI ATTIE, ALAN D · 2015 to 2019
$1.7M
Examining how the novel S64F MAFA variant produces glucose intolerance or hypoglycemia in a sex-dependent mannerK08DK132507 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeeyeon Cha · 2022 to 2026
$792k
Burroughs Wellcome Fund Career Award for Medical ScientistsNIDDK NIH HHS DK20593NIDDK NIH HHS K08 DK132507NIDDK NIH HHS R01 DK090570NIDDK NIH HHS R01DK101573NIDDK NIH HHS R01DK102948NIDDK NIH HHS RC2DK125961NIDDK NIH HHS T32 DK007563
6 · The paper itself

Abstract

aims/hypothesisIn monogenic diabetes, there is increasing recognition that common polygenic factors can modulate diabetes penetrance beyond the causative mutation(s). A naturally occurring mutation in the gene encoding the essential islet-enriched transcription factor MafA (MafA

methodsMafa

resultsMafa CONCLUSIONS/

interpretationIn sum, these data show that genetic modifiers can impact beta cell regulation of retinoic acid signalling and circadian entrainment to modulate beta cell ageing and disease penetrance in mice modelling MAFA-MODY. DATA AVAILABILITY: Sequencing data were deposited in the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database (accession no. GSE299343 for bulk RNA-seq and GSE298664 for CUT&RUN analyses).

Indexed as

Beta cellCellular senescenceCircadian rhythmMafAMODYPancreatic isletRetinoic acid

Identifiers

PMID42860432

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.