ReviewSports medicine - open2026
The Role of Glucose Metabolic Reprogramming in Exercise-Attenuated Osteoporosis: a Narrative Review.
Review in Sports medicine - open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
backgroundThe aging population has led to a significant increase in the prevalence of osteoporosis, making it an important public health issue. Emerging evidence suggests that osteoporosis is related to glucose metabolic reprogramming (GMR). Exercise is an effective non-pharmacological intervention method, and regulating GMR may be one of the pathways through which exercise improves bone health. MAIN BODY: GMR plays a critical role in regulating the function of bone cells. It influences the proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs), osteoblasts, osteocytes, and osteoclasts. Although the exact mechanisms remain to be fully elucidated, emerging studies suggest that metabolic shifts in glycolysis, the pentose phosphate pathway (PPP), and the tricarboxylic acid (TCA) cycle are critical regulators of bone homeostasis. Furthermore, preliminary evidence suggests that exercise modulates these metabolic pathways, thereby contributing to improved bone health and reduced osteoporotic risk.
conclusionThis narrative review provides new insights into the mechanistic understanding that GMR plays essential roles in the initiation and progression of osteoporosis. Different types of exercise may attenuate osteoporosis through the regulation of GMR.
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