SynthesisAdvances in therapy2026
Perinatal Outcomes of Pleuro-Amniotic Shunting in Isolated Pleural Effusions: Systematic Review and Meta-analysis.
Synthesis in Advances in therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
introductionPleuro-amniotic shunting has been proposed for fetal pleural effusion, although its safety and efficacy remain uncertain. Therefore, we aimed to evaluate the perinatal outcomes of the fetal therapy for isolated pleural effusion through a systematic review and single-arm meta-analysis.
methodsPubMed/MEDLINE, Embase, Scopus, and Cochrane Central were searched for studies reporting outcomes of fetuses undergoing pleuro-amniotic shunting for isolated pleural effusion. The primary outcomes were overall survival and resolution of fetal hydrops. Single-arm random-effects meta-analyses were performed to estimate pooled event rates with 95% confidence intervals (CI).
resultsTen retrospective cohort studies comprising 416 fetuses treated with pleuro-amniotic shunting were included. The pooled overall survival rate was 65.36% (95% CI 59.46-70.83; I
conclusionPleuro-amniotic shunting achieves overall survival in approximately two-thirds of treated fetuses and resolving fetal hydrops in most cases. However, the procedure may be associated with preterm birth and PROM, underscoring the need for multidisciplinary perinatal management. Although the evidence is limited, these findings support pleuro-amniotic shunting as a promising treatment for progressive isolated fetal pleural effusion and highlight the need for prospective studies to optimize patient selection and perinatal care.
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